Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling

The formation of protein complexes between phosphorylated R-Smads and Smad4 is a central event in the TGF-β signaling pathway. We have determined the crystal structure of two R-Smad/Smad4 complexes, Smad3/Smad4 to 2.5 Å, and Smad2/Smad4 to 2.7 Å. Both complexes are heterotrimers, comprising two phos...

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Veröffentlicht in:	Molecular cell 2004-09, Vol.15 (5), p.813-823
Hauptverfasser:	Chacko, Benoy M., Qin, Bin Y., Tiwari, Ashutosh, Shi, Genbin, Lam, Suvana, Hayward, Lawrence J., de Caestecker, Mark, Lin, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor COS Cells Crystallography, X-Ray DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Hot Temperature Macromolecular Substances Models, Molecular Molecular Conformation Phosphorylation Polymers - metabolism Protein Structure, Tertiary Protein Subunits - genetics Protein Subunits - metabolism Signal Transduction - physiology Smad2 Protein Smad3 Protein Temperature Trans-Activators - genetics Trans-Activators - metabolism Transforming Growth Factor beta - metabolism
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