A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia
Abstract Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia ( MLL ) gene rearrangements at 11q23, is...
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| Veröffentlicht in: | Cancer genetics and cytogenetics 2009-02, Vol.189 (1), p.59-62 |
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| creator | de Jesus Marques-Salles, Terezinha Liehr, Thomas Mkrtchyan, Hasmik Raimondi, Susana C Tavares de Souza, Mariana Faria de Figueiredo, Amanda Rouxinol, Soraia Jordy Macedo, Fernanda C Abdelhay, Eliana Santos, Neide Macedo Silva, Maria Luiza |
| description | Abstract Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia ( MLL ) gene rearrangements at 11q23, is of importance for the identification of biological subgroups, which might differ in drug resistance and/or clinical outcome. Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23). |
| doi_str_mv | 10.1016/j.cancergencyto.2008.10.009 |
| format | Article |
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Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia ( MLL ) gene rearrangements at 11q23, is of importance for the identification of biological subgroups, which might differ in drug resistance and/or clinical outcome. Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23).</description><identifier>ISSN: 0165-4608</identifier><identifier>EISSN: 1873-4456</identifier><identifier>DOI: 10.1016/j.cancergencyto.2008.10.009</identifier><identifier>PMID: 19167614</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Chromosomes, Human, Pair 11 - genetics ; Chromosomes, Human, Pair 19 - genetics ; Chromosomes, Human, Pair 9 - genetics ; Hematology, Oncology and Palliative Medicine ; Humans ; In Situ Hybridization, Fluorescence ; Infant ; Karyotyping ; Leukemia, Myeloid, Acute - genetics ; Male ; Medical Education ; Myeloid-Lymphoid Leukemia Protein - genetics ; Translocation, Genetic - genetics</subject><ispartof>Cancer genetics and cytogenetics, 2009-02, Vol.189 (1), p.59-62</ispartof><rights>Elsevier Inc.</rights><rights>2009 Elsevier Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-94dd73945cb6e2f03912a403ca7a47e177cd7dfc7ac655656ea376955469c8a33</citedby><cites>FETCH-LOGICAL-c436t-94dd73945cb6e2f03912a403ca7a47e177cd7dfc7ac655656ea376955469c8a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165460808005864$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19167614$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Jesus Marques-Salles, Terezinha</creatorcontrib><creatorcontrib>Liehr, Thomas</creatorcontrib><creatorcontrib>Mkrtchyan, Hasmik</creatorcontrib><creatorcontrib>Raimondi, Susana C</creatorcontrib><creatorcontrib>Tavares de Souza, Mariana</creatorcontrib><creatorcontrib>Faria de Figueiredo, Amanda</creatorcontrib><creatorcontrib>Rouxinol, Soraia</creatorcontrib><creatorcontrib>Jordy Macedo, Fernanda C</creatorcontrib><creatorcontrib>Abdelhay, Eliana</creatorcontrib><creatorcontrib>Santos, Neide</creatorcontrib><creatorcontrib>Macedo Silva, Maria Luiza</creatorcontrib><title>A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia</title><title>Cancer genetics and cytogenetics</title><addtitle>Cancer Genet Cytogenet</addtitle><description>Abstract Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). 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Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23).</description><subject>Chromosomes, Human, Pair 11 - genetics</subject><subject>Chromosomes, Human, Pair 19 - genetics</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Infant</subject><subject>Karyotyping</subject><subject>Leukemia, Myeloid, Acute - genetics</subject><subject>Male</subject><subject>Medical Education</subject><subject>Myeloid-Lymphoid Leukemia Protein - genetics</subject><subject>Translocation, Genetic - genetics</subject><issn>0165-4608</issn><issn>1873-4456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl2LEzEUhgdR3Lr6FyQgyO7F1GQmHzMUhGVZd4WKF-p1OM2ctmlnkprMtMyF_90MLYheSSC5OM97Dnk4WfaO0TmjTH7YzQ04g2GDzoy9nxeUVqkyp7R-ls1YpcqccyGfZ7NEi5xLWl1lr2LcUUpVUcuX2RWrmVSS8Vn26444PBGzDb7z0XfQkn4bEPMTjCQghABugx26nlh39O3Rug35slySDuIeG7IaCZD-pl6w-vbmwNjiwMrbhBJw6V5Dyp1svyVghh5JN2LrbUNaHPbYWXidvVhDG_HN5b3Ofnx6-H7_lC-_Pn6-v1vmhpeyz2veNKqsuTAricWaljUrgNPSgAKukCllGtWsjQIjhZBCIpRK1kJwWZsKyvI6e3_uewj-54Cx152NBtsWHPohaikrQQs6gYszaIKPMeBaH4LtIIyaUT3Z1zv9l3092Z-KyX5Kv72MGVYdNn-yF90JeDgDmD57tBh0NDY1wsYGNL1uvP3PQR__6WNa66yBdo8jxp0fgks-NdOx0FR_mxZh2oN0qKgkL38DymyyAQ</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>de Jesus Marques-Salles, Terezinha</creator><creator>Liehr, Thomas</creator><creator>Mkrtchyan, Hasmik</creator><creator>Raimondi, Susana C</creator><creator>Tavares de Souza, Mariana</creator><creator>Faria de Figueiredo, Amanda</creator><creator>Rouxinol, Soraia</creator><creator>Jordy Macedo, Fernanda C</creator><creator>Abdelhay, Eliana</creator><creator>Santos, Neide</creator><creator>Macedo Silva, Maria Luiza</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia</title><author>de Jesus Marques-Salles, Terezinha ; 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| subjects | Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 19 - genetics Chromosomes, Human, Pair 9 - genetics Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Infant Karyotyping Leukemia, Myeloid, Acute - genetics Male Medical Education Myeloid-Lymphoid Leukemia Protein - genetics Translocation, Genetic - genetics |
| title | A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia |
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