The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Myelodysplastic Syndromes: An Evidence-Based Review
Clinical research examining the role of hematopoietic stem cell transplantation (SCT) in the therapy of myelodysplastic syndromes (MDS) in adults is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for...
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| Veröffentlicht in: | Biology of blood and marrow transplantation 2009-02, Vol.15 (2), p.137-172 |
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| creator | Oliansky, Denise M Antin, Joseph H Bennett, John M Deeg, H. Joachim Engelhardt, Christin Heptinstall, Kathleen V de Lima, Marcos Gore, Steven D Potts, Ronald G Silverman, Lewis R Jones, Roy B McCarthy, Philip L Hahn, Theresa |
| description | Clinical research examining the role of hematopoietic stem cell transplantation (SCT) in the therapy of myelodysplastic syndromes (MDS) in adults is presented and critically evaluated in this systematic evidence-based review. Specific criteria were used for searching the published literature and for grading the quality and strength of the evidence and the strength of the treatment recommendations. Treatment recommendations based on the evidence are presented in Table 3 , and were reached unanimously by a panel of MDS experts. The identified priority areas of needed future research in MDS include: (1) the benefit of using alternative donor sources (eg, cord blood; haploidentical family donors) for patients without matched sibling or unrelated donors; (2) the role and appropriate timing of allogeneic SCT in combination with hypomethylating and immunomodulatory treatment regimens; (3) randomized trials comparing the safety and efficacy of various novel agents for treating MDS; and (4) the influence of the various MDS treatment modalities on patient-reported quality-of-life outcomes. |
| doi_str_mv | 10.1016/j.bbmt.2008.12.003 |
| format | Article |
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| ispartof | Biology of blood and marrow transplantation, 2009-02, Vol.15 (2), p.137-172 |
| issn | 1083-8791 1523-6536 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Antineoplastic Agents - therapeutic use Clinical Trials as Topic Evidence-Based Medicine Evidence-based review Hematology, Oncology and Palliative Medicine Hematopoietic stem cell transplantation Hematopoietic Stem Cell Transplantation - methods Humans Meta-Analysis as Topic Myelodysplastic syndromes Myelodysplastic Syndromes - diagnosis Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - therapy Prognosis Severity of Illness Index Therapy |
| title | The Role of Cytotoxic Therapy with Hematopoietic Stem Cell Transplantation in the Therapy of Myelodysplastic Syndromes: An Evidence-Based Review |
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