Incidence and outcome of endophthalmitis over a 13-year period
Abstract Objective: The aim of the study was to assess the functional results and long-term visual prognosis in patients treated for acute endophthalmitis (AE). Design: Observational clinical series. Participants: Evaluation of 120 eyes of 114 patients with AE treated between 1991 and 2004. Methods:...
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Veröffentlicht in: | Canadian journal of ophthalmology 2009-02, Vol.44 (1), p.88-94 |
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description | Abstract Objective: The aim of the study was to assess the functional results and long-term visual prognosis in patients treated for acute endophthalmitis (AE). Design: Observational clinical series. Participants: Evaluation of 120 eyes of 114 patients with AE treated between 1991 and 2004. Methods: This retrospective institutional analysis included 120 eyes of 114 patients (52 male, 68 female) with AE and a minimum follow-up of half a year. The patients had a mean follow-up of 23 months (6–135 months) and a mean age of 61 years (8 months-94 years) at the time of treatment. Treatment included intraocular injection of antibiotics alone ( n = 18, 15%) and vitrectomy combined with intraocular and topical postoperative antibiotics ( n = 85, 70%). Results: The most frequent complications were vitreous or retinal hemorrhages ( n = 17, 14%), retinal detachment ( n = 17, 14%), choroidal detachment ( n = 3, 3%), secondary glaucoma ( n = 7, 6%), and recurrent endophthalmitis ( n = 3, 3%). Four eyes had to be enucleated because of recurrent and uncontrollable infection. Positive microbiological results were achieved in 67 of 88 specimens (76%). The most common isolate was Staphylococcus. At the end of follow-up, visual acuity was reduced (more than 2 lines) in 18 eyes (15%), stable in 22 (18%), and improved (more than 2 lines) in 72 eyes (60%). Conclusions: AE is a rare but severe disease with a potentially deleterious outcome in affected eyes. In our series, 78% of all eyes had stable or improved postoperative visual acuity following various treatment regimens, depending on the severity of each case. |
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Design: Observational clinical series. Participants: Evaluation of 120 eyes of 114 patients with AE treated between 1991 and 2004. Methods: This retrospective institutional analysis included 120 eyes of 114 patients (52 male, 68 female) with AE and a minimum follow-up of half a year. The patients had a mean follow-up of 23 months (6–135 months) and a mean age of 61 years (8 months-94 years) at the time of treatment. Treatment included intraocular injection of antibiotics alone ( n = 18, 15%) and vitrectomy combined with intraocular and topical postoperative antibiotics ( n = 85, 70%). Results: The most frequent complications were vitreous or retinal hemorrhages ( n = 17, 14%), retinal detachment ( n = 17, 14%), choroidal detachment ( n = 3, 3%), secondary glaucoma ( n = 7, 6%), and recurrent endophthalmitis ( n = 3, 3%). Four eyes had to be enucleated because of recurrent and uncontrollable infection. Positive microbiological results were achieved in 67 of 88 specimens (76%). The most common isolate was Staphylococcus. At the end of follow-up, visual acuity was reduced (more than 2 lines) in 18 eyes (15%), stable in 22 (18%), and improved (more than 2 lines) in 72 eyes (60%). Conclusions: AE is a rare but severe disease with a potentially deleterious outcome in affected eyes. In our series, 78% of all eyes had stable or improved postoperative visual acuity following various treatment regimens, depending on the severity of each case.</description><identifier>ISSN: 0008-4182</identifier><identifier>EISSN: 1715-3360</identifier><identifier>DOI: 10.3129/i08-160</identifier><identifier>PMID: 19169320</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; antibiotics ; Bacteria - isolation & purification ; Child ; Child, Preschool ; Combined Modality Therapy ; endophthalmitis ; Endophthalmitis - epidemiology ; Endophthalmitis - microbiology ; Endophthalmitis - therapy ; England - epidemiology ; Eye Infections - epidemiology ; Eye Infections - microbiology ; Eye Infections - therapy ; Female ; Follow-Up Studies ; Fungi - isolation & purification ; Humans ; Incidence ; Infant ; Internal Medicine ; intraocular injection ; Male ; Middle Aged ; Ophthalmology ; Retrospective Studies ; Treatment Outcome ; Visual Acuity - physiology ; Vitrectomy ; Young Adult</subject><ispartof>Canadian journal of ophthalmology, 2009-02, Vol.44 (1), p.88-94</ispartof><rights>Canadian Ophthalmological Society</rights><rights>2009 Canadian Ophthalmological Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-45f814ee2360ade4d0baeb5180a70d7f6aef67cc6f1d046e63db415190d9d353</citedby><cites>FETCH-LOGICAL-c376t-45f814ee2360ade4d0baeb5180a70d7f6aef67cc6f1d046e63db415190d9d353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.3129/i08-160$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19169320$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krause, Lothar, MD</creatorcontrib><creatorcontrib>Bechrakis, Nikolaos E., MD</creatorcontrib><creatorcontrib>Heimann, Heinrich, MD</creatorcontrib><creatorcontrib>Kildal, Daniela, MS</creatorcontrib><creatorcontrib>Foerster, Michael H., MD</creatorcontrib><title>Incidence and outcome of endophthalmitis over a 13-year period</title><title>Canadian journal of ophthalmology</title><addtitle>Can J Ophthalmol</addtitle><description>Abstract Objective: The aim of the study was to assess the functional results and long-term visual prognosis in patients treated for acute endophthalmitis (AE). Design: Observational clinical series. Participants: Evaluation of 120 eyes of 114 patients with AE treated between 1991 and 2004. Methods: This retrospective institutional analysis included 120 eyes of 114 patients (52 male, 68 female) with AE and a minimum follow-up of half a year. The patients had a mean follow-up of 23 months (6–135 months) and a mean age of 61 years (8 months-94 years) at the time of treatment. Treatment included intraocular injection of antibiotics alone ( n = 18, 15%) and vitrectomy combined with intraocular and topical postoperative antibiotics ( n = 85, 70%). Results: The most frequent complications were vitreous or retinal hemorrhages ( n = 17, 14%), retinal detachment ( n = 17, 14%), choroidal detachment ( n = 3, 3%), secondary glaucoma ( n = 7, 6%), and recurrent endophthalmitis ( n = 3, 3%). Four eyes had to be enucleated because of recurrent and uncontrollable infection. Positive microbiological results were achieved in 67 of 88 specimens (76%). The most common isolate was Staphylococcus. At the end of follow-up, visual acuity was reduced (more than 2 lines) in 18 eyes (15%), stable in 22 (18%), and improved (more than 2 lines) in 72 eyes (60%). Conclusions: AE is a rare but severe disease with a potentially deleterious outcome in affected eyes. In our series, 78% of all eyes had stable or improved postoperative visual acuity following various treatment regimens, depending on the severity of each case.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibiotics</subject><subject>Bacteria - isolation & purification</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>endophthalmitis</subject><subject>Endophthalmitis - epidemiology</subject><subject>Endophthalmitis - microbiology</subject><subject>Endophthalmitis - therapy</subject><subject>England - epidemiology</subject><subject>Eye Infections - epidemiology</subject><subject>Eye Infections - microbiology</subject><subject>Eye Infections - therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fungi - isolation & purification</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Internal Medicine</subject><subject>intraocular injection</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Retrospective Studies</subject><subject>Treatment Outcome</subject><subject>Visual Acuity - physiology</subject><subject>Vitrectomy</subject><subject>Young Adult</subject><issn>0008-4182</issn><issn>1715-3360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkU1LxDAQhoMoun7gP5Ce9FSdado0vQgifoHgwb2HbDJlo22zJq2w_94suyCIp4HhmZeZZxg7R7jmWDQ3DmSOAvbYDGuscs4F7LMZQGqXKIsjdhzjBwDndSkO2RE2KBpewIzdvgzGWRoMZXqwmZ9G43vKfJvRYP1qOS5117vRxcx_U8h0hjxfkw7ZioLz9pQdtLqLdLarJ2z--DC_f85f355e7u9ec8NrMeZl1UosiYq0l7ZUWlhoWlQoQddg61ZoakVtjGjRQilIcLsoscIGbGN5xU_Y5TZ2FfzXRHFUvYuGuk4P5KeohJCllBUm8GoLmuBjDNSqVXC9DmuFoDamVDKlkqlEXuwip0VP9pfbqUkAbgFKd307CioatxFlXSAzKuvdP6G3f2ZM5wZndPdJa4offgpD0qRQxUKBet88aPMfaCQAyor_AMwmh5Y</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Krause, Lothar, MD</creator><creator>Bechrakis, Nikolaos E., MD</creator><creator>Heimann, Heinrich, MD</creator><creator>Kildal, Daniela, MS</creator><creator>Foerster, Michael H., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>Incidence and outcome of endophthalmitis over a 13-year period</title><author>Krause, Lothar, MD ; Bechrakis, Nikolaos E., MD ; Heimann, Heinrich, MD ; Kildal, Daniela, MS ; Foerster, Michael H., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-45f814ee2360ade4d0baeb5180a70d7f6aef67cc6f1d046e63db415190d9d353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>antibiotics</topic><topic>Bacteria - isolation & purification</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>endophthalmitis</topic><topic>Endophthalmitis - epidemiology</topic><topic>Endophthalmitis - microbiology</topic><topic>Endophthalmitis - therapy</topic><topic>England - epidemiology</topic><topic>Eye Infections - epidemiology</topic><topic>Eye Infections - microbiology</topic><topic>Eye Infections - therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Fungi - isolation & purification</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Internal Medicine</topic><topic>intraocular injection</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Retrospective Studies</topic><topic>Treatment Outcome</topic><topic>Visual Acuity - physiology</topic><topic>Vitrectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krause, Lothar, MD</creatorcontrib><creatorcontrib>Bechrakis, Nikolaos E., MD</creatorcontrib><creatorcontrib>Heimann, Heinrich, MD</creatorcontrib><creatorcontrib>Kildal, Daniela, MS</creatorcontrib><creatorcontrib>Foerster, Michael H., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krause, Lothar, MD</au><au>Bechrakis, Nikolaos E., MD</au><au>Heimann, Heinrich, MD</au><au>Kildal, Daniela, MS</au><au>Foerster, Michael H., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence and outcome of endophthalmitis over a 13-year period</atitle><jtitle>Canadian journal of ophthalmology</jtitle><addtitle>Can J Ophthalmol</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>44</volume><issue>1</issue><spage>88</spage><epage>94</epage><pages>88-94</pages><issn>0008-4182</issn><eissn>1715-3360</eissn><abstract>Abstract Objective: The aim of the study was to assess the functional results and long-term visual prognosis in patients treated for acute endophthalmitis (AE). Design: Observational clinical series. Participants: Evaluation of 120 eyes of 114 patients with AE treated between 1991 and 2004. Methods: This retrospective institutional analysis included 120 eyes of 114 patients (52 male, 68 female) with AE and a minimum follow-up of half a year. The patients had a mean follow-up of 23 months (6–135 months) and a mean age of 61 years (8 months-94 years) at the time of treatment. Treatment included intraocular injection of antibiotics alone ( n = 18, 15%) and vitrectomy combined with intraocular and topical postoperative antibiotics ( n = 85, 70%). Results: The most frequent complications were vitreous or retinal hemorrhages ( n = 17, 14%), retinal detachment ( n = 17, 14%), choroidal detachment ( n = 3, 3%), secondary glaucoma ( n = 7, 6%), and recurrent endophthalmitis ( n = 3, 3%). Four eyes had to be enucleated because of recurrent and uncontrollable infection. Positive microbiological results were achieved in 67 of 88 specimens (76%). The most common isolate was Staphylococcus. At the end of follow-up, visual acuity was reduced (more than 2 lines) in 18 eyes (15%), stable in 22 (18%), and improved (more than 2 lines) in 72 eyes (60%). Conclusions: AE is a rare but severe disease with a potentially deleterious outcome in affected eyes. In our series, 78% of all eyes had stable or improved postoperative visual acuity following various treatment regimens, depending on the severity of each case.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>19169320</pmid><doi>10.3129/i08-160</doi><tpages>7</tpages></addata></record> |
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subjects | Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use antibiotics Bacteria - isolation & purification Child Child, Preschool Combined Modality Therapy endophthalmitis Endophthalmitis - epidemiology Endophthalmitis - microbiology Endophthalmitis - therapy England - epidemiology Eye Infections - epidemiology Eye Infections - microbiology Eye Infections - therapy Female Follow-Up Studies Fungi - isolation & purification Humans Incidence Infant Internal Medicine intraocular injection Male Middle Aged Ophthalmology Retrospective Studies Treatment Outcome Visual Acuity - physiology Vitrectomy Young Adult |
title | Incidence and outcome of endophthalmitis over a 13-year period |
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