Chymase-Dependent Conversion of Big Endothelin-1 in the Mouse in Vivo

The aim of this study was to identify the role of chymase in the conversion of exogenously administered Big endothelin-1 in the mouse in vivo. Real-time polymerase chain reaction analysis detected mRNA of mucosal mast cell chymases 4 and 5, endothelin-converting enzyme 1a, and neutral endopeptidase...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2009-02, Vol.328 (2), p.540-548
Hauptverfasser:	Simard, Elie, Jin, Denan, Takai, Shinji, Miyazaki, Mizuo, Brochu, Isabelle, D’Orléans-Juste, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Chymases - metabolism Endothelin-1 - metabolism Male Mice Mice, Inbred C57BL Receptors, Endothelin - metabolism RNA, Messenger - metabolism Serine Endopeptidases - genetics Serine Endopeptidases - metabolism
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