Micro and nano-fabrication of biodegradable polymers for drug delivery

This paper presents state-of-the-art micro and nano-fabrication techniques for biodegradable polymers. Replication molding, using a rigid or elastic master, can pattern structures on a polymer surface in a submicron resolution at a low cost. Layer-by-layer rapid prototyping methods are promising in...

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Veröffentlicht in:Advanced drug delivery reviews 2004-09, Vol.56 (11), p.1621-1633
Hauptverfasser: Lu, Y., Chen, S.C.
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Chen, S.C.
description This paper presents state-of-the-art micro and nano-fabrication techniques for biodegradable polymers. Replication molding, using a rigid or elastic master, can pattern structures on a polymer surface in a submicron resolution at a low cost. Layer-by-layer rapid prototyping methods are promising in producing controlled release units with complicated geometries, release mechanisms and the ability to control microstructure and composition. Special attention is paid to the fast, flexible, and non-invasive laser fabrication techniques that have great potential in the fabrication of biodegradable polymer drug delivery devices in both a laboratory and industry scale.
doi_str_mv 10.1016/j.addr.2004.05.002
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subjects Absorbable Implants
Biodegradable polymer
Capsules
Drug delivery
Drug Delivery Systems - methods
Microfabrication
Nanofabrication
Nanotechnology - methods
Polymers - administration & dosage
Polymers - chemical synthesis
title Micro and nano-fabrication of biodegradable polymers for drug delivery
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