A theory of optimal differential gene expression

We investigate a model of optimal regulation, intended to describe large-scale differential gene expression. Relations between the optimal expression patterns and the function of genes are deduced from an optimality principle: the regulators have to maximise a fitness function which they influence d...

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Veröffentlicht in:	BioSystems 2004-08, Vol.76 (1), p.261-278
Hauptverfasser:	Liebermeister, Wolfram, Klipp, Edda, Schuster, Stefan, Heinrich, Reinhart
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Animals Cell Physiological Phenomena Feedback - physiology Gene expression Gene Expression Regulation - physiology Gene function Genes, Regulator - genetics Genetic regulation Humans Linear model Metabolic control analysis Models, Genetic Multienzyme Complexes - metabolism Optimality principle Signal Transduction - physiology Transcription Factors - metabolism
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