Inactivation of p53 and amplification of MYCN gene in a terminal lymphoblastic relapse in a chronic lymphocytic leukemia patient

Abstract B-cell chronic lymphocytic leukemia (CLL) is an incurable disease with a highly variable clinical course. A proportion of patients eventually progress to a higher stage of malignancy. A recent association has been observed between the presence of aberrant somatic hypermutations in leukemic...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cancer genetics and cytogenetics 2009-02, Vol.189 (1), p.53-58
Hauptverfasser:	Stano-Kozubik, Katerina, Malcikova, Jitka, Tichy, Boris, Kotaskova, Jana, Borsky, Marek, Hrabcakova, Viera, Francova, Hana, Valaskova, Iveta, Bourkova, Ludmila, Smardova, Jana, Doubek, Michael, Brychtova, Yvona, Pospisilova, Sarka, Mayer, Jiri, Trbusek, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Gene Amplification Hematology, Oncology and Palliative Medicine Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - prevention & control Male Medical Education Middle Aged N-Myc Proto-Oncogene Protein Nuclear Proteins - genetics Oncogene Proteins - genetics Recurrence Somatic Hypermutation, Immunoglobulin - genetics Tumor Suppressor Protein p53 - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!