SRA coactivation of estrogen receptor-α is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity

The ability of steroid receptor RNA activator (SRA), an AF-1 coactivator, to contribute to differences in estrogen receptor (ER)-α and ERβ transcriptional activity was tested. In transient transfections, SRA expression increased ERα- and ERβ-dependent gene expression. However, when the receptors’ am...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-10, Vol.323 (1), p.332-338
Hauptverfasser:	Coleman, Kevin M., Lam, Vinh, Jaber, Basem M., Lanz, Rainer B., Smith, Carolyn L.
Format:	Artikel
Sprache:	eng
Schlagworte:	AF-1 Blotting, Western Cell Line Coactivator DNA - metabolism Drug Resistance, Neoplasm ERα ERβ Estrogen Receptor alpha - metabolism Estrogen Receptor beta - metabolism Estrogen receptors Gene Deletion Gene Expression Regulation HeLa Cells Humans Mutation Phosphorylation Plasmids - metabolism Protein Structure, Tertiary RNA, Long Noncoding RNA, Untranslated - metabolism RNA, Untranslated - physiology SRA Tamoxifen Tamoxifen - agonists Tamoxifen - analogs & derivatives Tamoxifen - pharmacology Transcription, Genetic Transfection
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