Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas
Abstract Objective Meningiomas are the most common neoplasms of the central nervous system and are more frequent in women than in men. Many studies have been conducted to determine whether the progesterone receptor (PR) and estrogen receptor (ER) are present or absent in meningiomas. No previous stu...
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| Veröffentlicht in: | Clinical neurology and neurosurgery 2009-02, Vol.111 (2), p.127-133 |
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| creator | Hirota, Yuichi Tachibana, Osamu Uchiyama, Naoyuki Hayashi, Yasuhiko Nakada, Mitsutoshi Kita, Daisuke Watanabe, Takuya Higashi, Ryo Hamada, Jun-ichiro Hayashi, Yutaka |
| description | Abstract Objective Meningiomas are the most common neoplasms of the central nervous system and are more frequent in women than in men. Many studies have been conducted to determine whether the progesterone receptor (PR) and estrogen receptor (ER) are present or absent in meningiomas. No previous studies, however, have investigated the status (presence or absence) of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R), two major factors related to PR and ER, in meningiomas. This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas. Methods Eighty-two specimens of human meningiomas were obtained for immunohistochemical analysis with anti-GnRH, anti-GnRH-R, anti-PR, anti-ER, and anti-Ki-67 (MIB-1) antibodies, and for RT-PCR analysis of the mRNA expressions of GnRH and GnRH-R. Correlations of GnRH and GnRH-R with PR, ER, Ki-67, and clinical features such as age, sex, tumor grade, and tumor histology were assessed. Results Seventy-eight (95.1%) of the 82 meningiomas reacted positively in the cytoplasm for the GnRH-R. Forty-nine (59.8%) of the 82 cases reacted positively in the cytoplasm for the GnRH. The positive immunoreactivity for GnRH-R and GnRH was confirmed by the RT-PCR analyses of mRNA. Forty-seven (96%) of the 49 cases with positive immunoreactivity for GnRH-R also had positive immunoreactivity for GnRH. PR expression was higher in the tumors positive for GnRH-R ( p = 0.002), and a significantly higher proportion of tumors from male patients exhibited positive immunoreactivity for GnRH ( p = 0.02). No significant correlations were found between the status of GnRH-R or GnRH with other clinicopathological features. Conclusion Over half of meningiomas may be regulated by GnRH–GnRH-R expression in an autocrine fashion. This unique expression profile of GnRH and GnRH-R may open the way to the development of GnRH analogs as a treatment tool in the future. |
| doi_str_mv | 10.1016/j.clineuro.2008.09.015 |
| format | Article |
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Many studies have been conducted to determine whether the progesterone receptor (PR) and estrogen receptor (ER) are present or absent in meningiomas. No previous studies, however, have investigated the status (presence or absence) of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R), two major factors related to PR and ER, in meningiomas. This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas. Methods Eighty-two specimens of human meningiomas were obtained for immunohistochemical analysis with anti-GnRH, anti-GnRH-R, anti-PR, anti-ER, and anti-Ki-67 (MIB-1) antibodies, and for RT-PCR analysis of the mRNA expressions of GnRH and GnRH-R. Correlations of GnRH and GnRH-R with PR, ER, Ki-67, and clinical features such as age, sex, tumor grade, and tumor histology were assessed. Results Seventy-eight (95.1%) of the 82 meningiomas reacted positively in the cytoplasm for the GnRH-R. Forty-nine (59.8%) of the 82 cases reacted positively in the cytoplasm for the GnRH. The positive immunoreactivity for GnRH-R and GnRH was confirmed by the RT-PCR analyses of mRNA. Forty-seven (96%) of the 49 cases with positive immunoreactivity for GnRH-R also had positive immunoreactivity for GnRH. PR expression was higher in the tumors positive for GnRH-R ( p = 0.002), and a significantly higher proportion of tumors from male patients exhibited positive immunoreactivity for GnRH ( p = 0.02). No significant correlations were found between the status of GnRH-R or GnRH with other clinicopathological features. Conclusion Over half of meningiomas may be regulated by GnRH–GnRH-R expression in an autocrine fashion. This unique expression profile of GnRH and GnRH-R may open the way to the development of GnRH analogs as a treatment tool in the future.</description><identifier>ISSN: 0303-8467</identifier><identifier>EISSN: 1872-6968</identifier><identifier>DOI: 10.1016/j.clineuro.2008.09.015</identifier><identifier>PMID: 18980792</identifier><identifier>CODEN: CNNSBV</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Cancer therapies ; Estrogen receptor (ER) ; Female ; Gonadotropin-releasing hormone (GnRH) ; Gonadotropin-Releasing Hormone - genetics ; Gonadotropin-Releasing Hormone - metabolism ; Gonadotropin-releasing hormone receptor (GnRH-R) ; Hormones ; Humans ; Immunohistochemistry ; Ki-67 Antigen - metabolism ; Male ; Medical sciences ; Meningeal Neoplasms - genetics ; Meningeal Neoplasms - metabolism ; Meningeal Neoplasms - pathology ; Meningioma - genetics ; Meningioma - metabolism ; Meningioma - pathology ; Meningiomas ; Middle Aged ; Neurology ; Neurosurgery ; Progesterone receptor (PR) ; Receptors, Estrogen - metabolism ; Receptors, LHRH - genetics ; Receptors, LHRH - metabolism ; Receptors, Progesterone - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sex Factors ; Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tumors ; Womens health ; Young Adult</subject><ispartof>Clinical neurology and neurosurgery, 2009-02, Vol.111 (2), p.127-133</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-fa901d9e7432c6b94df7b9c7d6da539754ddf4b5c0bf5fe9a52912dfb256b1fd3</citedby><cites>FETCH-LOGICAL-c545t-fa901d9e7432c6b94df7b9c7d6da539754ddf4b5c0bf5fe9a52912dfb256b1fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1033184056?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21100207$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18980792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hirota, Yuichi</creatorcontrib><creatorcontrib>Tachibana, Osamu</creatorcontrib><creatorcontrib>Uchiyama, Naoyuki</creatorcontrib><creatorcontrib>Hayashi, Yasuhiko</creatorcontrib><creatorcontrib>Nakada, Mitsutoshi</creatorcontrib><creatorcontrib>Kita, Daisuke</creatorcontrib><creatorcontrib>Watanabe, Takuya</creatorcontrib><creatorcontrib>Higashi, Ryo</creatorcontrib><creatorcontrib>Hamada, Jun-ichiro</creatorcontrib><creatorcontrib>Hayashi, Yutaka</creatorcontrib><title>Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas</title><title>Clinical neurology and neurosurgery</title><addtitle>Clin Neurol Neurosurg</addtitle><description>Abstract Objective Meningiomas are the most common neoplasms of the central nervous system and are more frequent in women than in men. Many studies have been conducted to determine whether the progesterone receptor (PR) and estrogen receptor (ER) are present or absent in meningiomas. No previous studies, however, have investigated the status (presence or absence) of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R), two major factors related to PR and ER, in meningiomas. This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas. Methods Eighty-two specimens of human meningiomas were obtained for immunohistochemical analysis with anti-GnRH, anti-GnRH-R, anti-PR, anti-ER, and anti-Ki-67 (MIB-1) antibodies, and for RT-PCR analysis of the mRNA expressions of GnRH and GnRH-R. Correlations of GnRH and GnRH-R with PR, ER, Ki-67, and clinical features such as age, sex, tumor grade, and tumor histology were assessed. Results Seventy-eight (95.1%) of the 82 meningiomas reacted positively in the cytoplasm for the GnRH-R. Forty-nine (59.8%) of the 82 cases reacted positively in the cytoplasm for the GnRH. The positive immunoreactivity for GnRH-R and GnRH was confirmed by the RT-PCR analyses of mRNA. Forty-seven (96%) of the 49 cases with positive immunoreactivity for GnRH-R also had positive immunoreactivity for GnRH. PR expression was higher in the tumors positive for GnRH-R ( p = 0.002), and a significantly higher proportion of tumors from male patients exhibited positive immunoreactivity for GnRH ( p = 0.02). No significant correlations were found between the status of GnRH-R or GnRH with other clinicopathological features. Conclusion Over half of meningiomas may be regulated by GnRH–GnRH-R expression in an autocrine fashion. This unique expression profile of GnRH and GnRH-R may open the way to the development of GnRH analogs as a treatment tool in the future.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Cancer therapies</subject><subject>Estrogen receptor (ER)</subject><subject>Female</subject><subject>Gonadotropin-releasing hormone (GnRH)</subject><subject>Gonadotropin-Releasing Hormone - genetics</subject><subject>Gonadotropin-Releasing Hormone - metabolism</subject><subject>Gonadotropin-releasing hormone receptor (GnRH-R)</subject><subject>Hormones</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Meningeal Neoplasms - genetics</subject><subject>Meningeal Neoplasms - metabolism</subject><subject>Meningeal Neoplasms - pathology</subject><subject>Meningioma - genetics</subject><subject>Meningioma - metabolism</subject><subject>Meningioma - pathology</subject><subject>Meningiomas</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Neurosurgery</subject><subject>Progesterone receptor (PR)</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Receptors, LHRH - genetics</subject><subject>Receptors, LHRH - metabolism</subject><subject>Receptors, Progesterone - metabolism</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Sex Factors</subject><subject>Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. 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Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tumors</topic><topic>Womens health</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hirota, Yuichi</creatorcontrib><creatorcontrib>Tachibana, Osamu</creatorcontrib><creatorcontrib>Uchiyama, Naoyuki</creatorcontrib><creatorcontrib>Hayashi, Yasuhiko</creatorcontrib><creatorcontrib>Nakada, Mitsutoshi</creatorcontrib><creatorcontrib>Kita, Daisuke</creatorcontrib><creatorcontrib>Watanabe, Takuya</creatorcontrib><creatorcontrib>Higashi, Ryo</creatorcontrib><creatorcontrib>Hamada, Jun-ichiro</creatorcontrib><creatorcontrib>Hayashi, Yutaka</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical neurology and neurosurgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirota, Yuichi</au><au>Tachibana, Osamu</au><au>Uchiyama, Naoyuki</au><au>Hayashi, Yasuhiko</au><au>Nakada, Mitsutoshi</au><au>Kita, Daisuke</au><au>Watanabe, Takuya</au><au>Higashi, Ryo</au><au>Hamada, Jun-ichiro</au><au>Hayashi, Yutaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas</atitle><jtitle>Clinical neurology and neurosurgery</jtitle><addtitle>Clin Neurol Neurosurg</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>111</volume><issue>2</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0303-8467</issn><eissn>1872-6968</eissn><coden>CNNSBV</coden><abstract>Abstract Objective Meningiomas are the most common neoplasms of the central nervous system and are more frequent in women than in men. Many studies have been conducted to determine whether the progesterone receptor (PR) and estrogen receptor (ER) are present or absent in meningiomas. No previous studies, however, have investigated the status (presence or absence) of gonadotropin-releasing hormone (GnRH) and its receptor (GnRH-R), two major factors related to PR and ER, in meningiomas. This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas. Methods Eighty-two specimens of human meningiomas were obtained for immunohistochemical analysis with anti-GnRH, anti-GnRH-R, anti-PR, anti-ER, and anti-Ki-67 (MIB-1) antibodies, and for RT-PCR analysis of the mRNA expressions of GnRH and GnRH-R. Correlations of GnRH and GnRH-R with PR, ER, Ki-67, and clinical features such as age, sex, tumor grade, and tumor histology were assessed. Results Seventy-eight (95.1%) of the 82 meningiomas reacted positively in the cytoplasm for the GnRH-R. Forty-nine (59.8%) of the 82 cases reacted positively in the cytoplasm for the GnRH. The positive immunoreactivity for GnRH-R and GnRH was confirmed by the RT-PCR analyses of mRNA. Forty-seven (96%) of the 49 cases with positive immunoreactivity for GnRH-R also had positive immunoreactivity for GnRH. PR expression was higher in the tumors positive for GnRH-R ( p = 0.002), and a significantly higher proportion of tumors from male patients exhibited positive immunoreactivity for GnRH ( p = 0.02). No significant correlations were found between the status of GnRH-R or GnRH with other clinicopathological features. Conclusion Over half of meningiomas may be regulated by GnRH–GnRH-R expression in an autocrine fashion. This unique expression profile of GnRH and GnRH-R may open the way to the development of GnRH analogs as a treatment tool in the future.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>18980792</pmid><doi>10.1016/j.clineuro.2008.09.015</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Biological and medical sciences Cancer therapies Estrogen receptor (ER) Female Gonadotropin-releasing hormone (GnRH) Gonadotropin-Releasing Hormone - genetics Gonadotropin-Releasing Hormone - metabolism Gonadotropin-releasing hormone receptor (GnRH-R) Hormones Humans Immunohistochemistry Ki-67 Antigen - metabolism Male Medical sciences Meningeal Neoplasms - genetics Meningeal Neoplasms - metabolism Meningeal Neoplasms - pathology Meningioma - genetics Meningioma - metabolism Meningioma - pathology Meningiomas Middle Aged Neurology Neurosurgery Progesterone receptor (PR) Receptors, Estrogen - metabolism Receptors, LHRH - genetics Receptors, LHRH - metabolism Receptors, Progesterone - metabolism Reverse Transcriptase Polymerase Chain Reaction Sex Factors Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tumors Womens health Young Adult |
| title | Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T00%3A19%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gonadotropin-releasing%20hormone%20(GnRH)%20and%20its%20receptor%20in%20human%20meningiomas&rft.jtitle=Clinical%20neurology%20and%20neurosurgery&rft.au=Hirota,%20Yuichi&rft.date=2009-02-01&rft.volume=111&rft.issue=2&rft.spage=127&rft.epage=133&rft.pages=127-133&rft.issn=0303-8467&rft.eissn=1872-6968&rft.coden=CNNSBV&rft_id=info:doi/10.1016/j.clineuro.2008.09.015&rft_dat=%3Cproquest_cross%3E66846822%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1033184056&rft_id=info:pmid/18980792&rft_els_id=1_s2_0_S0303846708003089&rfr_iscdi=true |