Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L
Acetylcholinesterase guided fractionation of Melissa officinalis L. was carried out and the contents out and the contents of the most potent fraction were identified as cis- and trans-rosmarinic acids and a derivative of rosmarinic acid. The plant Melissa officinalis L. has been used traditionally i...
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| Veröffentlicht in: | Bioorganic & medicinal chemistry 2009-01, Vol.17 (2), p.867-871 |
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| container_title | Bioorganic & medicinal chemistry |
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| creator | Dastmalchi, Keyvan Ollilainen, Velimatti Lackman, Petri Gennäs, Gustav Boije af Dorman, H.J. Damien Järvinen, Päivi P. Yli-Kauhaluoma, Jari Hiltunen, Raimo |
| description | Acetylcholinesterase guided fractionation of
Melissa officinalis L. was carried out and the contents out and the contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acids and a derivative of rosmarinic acid.
The plant
Melissa officinalis L. has been used traditionally in the treatment of cognitive dysfunction. Based on its traditional medicinal use, it was assessed for its clinical efficacy in mild to moderate Alzheimer’s patients. The plant was effective in the management of the disease. Therefore, based on this result, a similar plant extract was prepared in order to be screened for bioactivities which are relevant in Alzheimer’s disease therapy. The extract was recently screened for antioxidant activity and it showed a wide range of antioxidant properties. Another important bioactivity is acetylcholinesterase inhibition, which the extract was screened for in the current investigation. The extract was capable of inhibiting the enzyme in a time and dose-dependent manner. Activity of the extract at 10
min was estimated as 1.72
±
0.16
μg equivalents of physostigmine/mg of the extract. Acetylcholinesterase inhibitory guided fractionation of the extract was then carried out. Most of the fractions showed inhibitory activity and were more potent than the extract. The contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acid isomers and a rosmarinic acid derivative using LC-DAD-ESI-MS and NMR methods. |
| doi_str_mv | 10.1016/j.bmc.2008.11.034 |
| format | Article |
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Melissa officinalis L. was carried out and the contents out and the contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acids and a derivative of rosmarinic acid.
The plant
Melissa officinalis L. has been used traditionally in the treatment of cognitive dysfunction. Based on its traditional medicinal use, it was assessed for its clinical efficacy in mild to moderate Alzheimer’s patients. The plant was effective in the management of the disease. Therefore, based on this result, a similar plant extract was prepared in order to be screened for bioactivities which are relevant in Alzheimer’s disease therapy. The extract was recently screened for antioxidant activity and it showed a wide range of antioxidant properties. Another important bioactivity is acetylcholinesterase inhibition, which the extract was screened for in the current investigation. The extract was capable of inhibiting the enzyme in a time and dose-dependent manner. Activity of the extract at 10
min was estimated as 1.72
±
0.16
μg equivalents of physostigmine/mg of the extract. Acetylcholinesterase inhibitory guided fractionation of the extract was then carried out. Most of the fractions showed inhibitory activity and were more potent than the extract. The contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acid isomers and a rosmarinic acid derivative using LC-DAD-ESI-MS and NMR methods.</description><identifier>ISSN: 0968-0896</identifier><identifier>EISSN: 1464-3391</identifier><identifier>DOI: 10.1016/j.bmc.2008.11.034</identifier><identifier>PMID: 19070498</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Acetylcholinesterase inhibition ; Activity-guided fractionation ; Alzheimer Disease - drug therapy ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Aroma and flavouring agent industries ; Biological and medical sciences ; Cholinesterase Inhibitors - isolation & purification ; Cholinesterase Inhibitors - pharmacology ; Cinnamates ; cis-Rosmarinic acid ; Depsides ; Food industries ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; Humans ; Kinetics ; Medical sciences ; Melissa - chemistry ; Melissa officinalis ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Rosmarinic Acid ; trans-Rosmarinic acid</subject><ispartof>Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.867-871</ispartof><rights>2008 Elsevier Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-47b71f3189b8c3b2cfe7126e99116854793cbfa6b9c0b9315d4da5c9a303825a3</citedby><cites>FETCH-LOGICAL-c478t-47b71f3189b8c3b2cfe7126e99116854793cbfa6b9c0b9315d4da5c9a303825a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0968089608011115$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21127125$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19070498$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dastmalchi, Keyvan</creatorcontrib><creatorcontrib>Ollilainen, Velimatti</creatorcontrib><creatorcontrib>Lackman, Petri</creatorcontrib><creatorcontrib>Gennäs, Gustav Boije af</creatorcontrib><creatorcontrib>Dorman, H.J. Damien</creatorcontrib><creatorcontrib>Järvinen, Päivi P.</creatorcontrib><creatorcontrib>Yli-Kauhaluoma, Jari</creatorcontrib><creatorcontrib>Hiltunen, Raimo</creatorcontrib><title>Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L</title><title>Bioorganic & medicinal chemistry</title><addtitle>Bioorg Med Chem</addtitle><description>Acetylcholinesterase guided fractionation of
Melissa officinalis L. was carried out and the contents out and the contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acids and a derivative of rosmarinic acid.
The plant
Melissa officinalis L. has been used traditionally in the treatment of cognitive dysfunction. Based on its traditional medicinal use, it was assessed for its clinical efficacy in mild to moderate Alzheimer’s patients. The plant was effective in the management of the disease. Therefore, based on this result, a similar plant extract was prepared in order to be screened for bioactivities which are relevant in Alzheimer’s disease therapy. The extract was recently screened for antioxidant activity and it showed a wide range of antioxidant properties. Another important bioactivity is acetylcholinesterase inhibition, which the extract was screened for in the current investigation. The extract was capable of inhibiting the enzyme in a time and dose-dependent manner. Activity of the extract at 10
min was estimated as 1.72
±
0.16
μg equivalents of physostigmine/mg of the extract. Acetylcholinesterase inhibitory guided fractionation of the extract was then carried out. Most of the fractions showed inhibitory activity and were more potent than the extract. The contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acid isomers and a rosmarinic acid derivative using LC-DAD-ESI-MS and NMR methods.</description><subject>Acetylcholinesterase inhibition</subject><subject>Activity-guided fractionation</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Aroma and flavouring agent industries</subject><subject>Biological and medical sciences</subject><subject>Cholinesterase Inhibitors - isolation & purification</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Cinnamates</subject><subject>cis-Rosmarinic acid</subject><subject>Depsides</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Medical sciences</subject><subject>Melissa - chemistry</subject><subject>Melissa officinalis</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Rosmarinic Acid</subject><subject>trans-Rosmarinic acid</subject><issn>0968-0896</issn><issn>1464-3391</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi3UqizQH9BLlUt7S_DEjmOLE0LlQ1rUSzlb9mQCXmUTsLNI--_r1a7gBhePR3re0czD2A_gFXBQ56vKr7GqOdcVQMWFPGILkEqWQhj4whbcKF1ybdQxO0lpxTmvpYFv7BgMb7k0esHuL5Hm7YBP0xBGSjNFl6gI41PwYZ7itnjchI66oo8O5zCNbvcUU1_c0xBScvnbBwyjy12xPGNfezck-n6op-zh-s-_q9ty-ffm7upyWaJs9VzK1rfQC9DGaxS-xp5aqBUZA6B0I1sj0PdOeYPcGwFNJzvXoHGCC103Tpyy3_u5z3F62eS17TokpGFwI02bZJXSUjXafArWWZrmos0g7EGMU0qRevscw9rFrQVud7LtymbZdifbAticy5mfh-Ebv6buPXGwm4FfB8AldEN2OGJIb1wNUOe7m8xd7DnKzl4DRZsw0IjUhUg4224KH6zxH6SQnFo</recordid><startdate>20090115</startdate><enddate>20090115</enddate><creator>Dastmalchi, Keyvan</creator><creator>Ollilainen, Velimatti</creator><creator>Lackman, Petri</creator><creator>Gennäs, Gustav Boije af</creator><creator>Dorman, H.J. Damien</creator><creator>Järvinen, Päivi P.</creator><creator>Yli-Kauhaluoma, Jari</creator><creator>Hiltunen, Raimo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20090115</creationdate><title>Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L</title><author>Dastmalchi, Keyvan ; Ollilainen, Velimatti ; Lackman, Petri ; Gennäs, Gustav Boije af ; Dorman, H.J. Damien ; Järvinen, Päivi P. ; Yli-Kauhaluoma, Jari ; Hiltunen, Raimo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-47b71f3189b8c3b2cfe7126e99116854793cbfa6b9c0b9315d4da5c9a303825a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Acetylcholinesterase inhibition</topic><topic>Activity-guided fractionation</topic><topic>Alzheimer Disease - drug therapy</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Aroma and flavouring agent industries</topic><topic>Biological and medical sciences</topic><topic>Cholinesterase Inhibitors - isolation & purification</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Cinnamates</topic><topic>cis-Rosmarinic acid</topic><topic>Depsides</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Medical sciences</topic><topic>Melissa - chemistry</topic><topic>Melissa officinalis</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Rosmarinic Acid</topic><topic>trans-Rosmarinic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dastmalchi, Keyvan</creatorcontrib><creatorcontrib>Ollilainen, Velimatti</creatorcontrib><creatorcontrib>Lackman, Petri</creatorcontrib><creatorcontrib>Gennäs, Gustav Boije af</creatorcontrib><creatorcontrib>Dorman, H.J. Damien</creatorcontrib><creatorcontrib>Järvinen, Päivi P.</creatorcontrib><creatorcontrib>Yli-Kauhaluoma, Jari</creatorcontrib><creatorcontrib>Hiltunen, Raimo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Bioorganic & medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dastmalchi, Keyvan</au><au>Ollilainen, Velimatti</au><au>Lackman, Petri</au><au>Gennäs, Gustav Boije af</au><au>Dorman, H.J. Damien</au><au>Järvinen, Päivi P.</au><au>Yli-Kauhaluoma, Jari</au><au>Hiltunen, Raimo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L</atitle><jtitle>Bioorganic & medicinal chemistry</jtitle><addtitle>Bioorg Med Chem</addtitle><date>2009-01-15</date><risdate>2009</risdate><volume>17</volume><issue>2</issue><spage>867</spage><epage>871</epage><pages>867-871</pages><issn>0968-0896</issn><eissn>1464-3391</eissn><abstract>Acetylcholinesterase guided fractionation of
Melissa officinalis L. was carried out and the contents out and the contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acids and a derivative of rosmarinic acid.
The plant
Melissa officinalis L. has been used traditionally in the treatment of cognitive dysfunction. Based on its traditional medicinal use, it was assessed for its clinical efficacy in mild to moderate Alzheimer’s patients. The plant was effective in the management of the disease. Therefore, based on this result, a similar plant extract was prepared in order to be screened for bioactivities which are relevant in Alzheimer’s disease therapy. The extract was recently screened for antioxidant activity and it showed a wide range of antioxidant properties. Another important bioactivity is acetylcholinesterase inhibition, which the extract was screened for in the current investigation. The extract was capable of inhibiting the enzyme in a time and dose-dependent manner. Activity of the extract at 10
min was estimated as 1.72
±
0.16
μg equivalents of physostigmine/mg of the extract. Acetylcholinesterase inhibitory guided fractionation of the extract was then carried out. Most of the fractions showed inhibitory activity and were more potent than the extract. The contents of the most potent fraction were identified as
cis- and
trans-rosmarinic acid isomers and a rosmarinic acid derivative using LC-DAD-ESI-MS and NMR methods.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>19070498</pmid><doi>10.1016/j.bmc.2008.11.034</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0968-0896 |
| ispartof | Bioorganic & medicinal chemistry, 2009-01, Vol.17 (2), p.867-871 |
| issn | 0968-0896 1464-3391 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase inhibition Activity-guided fractionation Alzheimer Disease - drug therapy Antioxidants - isolation & purification Antioxidants - pharmacology Aroma and flavouring agent industries Biological and medical sciences Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Cinnamates cis-Rosmarinic acid Depsides Food industries Fundamental and applied biological sciences. Psychology General pharmacology Humans Kinetics Medical sciences Melissa - chemistry Melissa officinalis Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Rosmarinic Acid trans-Rosmarinic acid |
| title | Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L |
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