The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease
Objective To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale––Revised (WAIS‐R) and the Wechsler Memory Scale––Revised (WMS‐R). Design We examined the WAIS‐R and the WMS‐R...
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| Veröffentlicht in: | International journal of geriatric psychiatry 2009-02, Vol.24 (2), p.125-131 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Oda, Haruhiko Yamamoto, Yasuji Maeda, Kiyoshi |
| description | Objective
To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale––Revised (WAIS‐R) and the Wechsler Memory Scale––Revised (WMS‐R).
Design
We examined the WAIS‐R and the WMS‐R of 26 patients with probable DLB (based on the Consensus Criteria for the clinical diagnosis of DLB) and of 78 patients with probable Alzheimer's disease (AD) (based on criteria of the National Institute for Neurological and Communicative Disorders and Stroke‐Alzheimer's disease and Related Disorders Association) who were matched to the patients with DLB 3:1 by Mini‐Mental State Examination score.
Results
The DLB group scored significantly lower on the Block Design, Object Assembly and Digit Symbol of WAIS‐R and significantly higher on the Logical Memory I, Verbal Paired Associates I, Logical Memory II, Visual Paired Associates II, Verbal Paired Associates II and Visual Reproduction II of WMS‐R (p |
| doi_str_mv | 10.1002/gps.2078 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66846325</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1631487731</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4458-62247f785671d6de53ab86794ed20d1bf36cd3858275844458377d9d277051b3</originalsourceid><addsrcrecordid>eNqF0VtrFDEUB_AgFrutgp9AgtDqy9RcJpd5LKuupYtauiD4EjKTM93UuazJDuv66c2wQwuC-JSH_HLOyfkj9JKSC0oIe3e3iReMKP0EzSgpioxSKZ-iGdFaZJJxcoxOYrwnJN1R_QwdUy2pUErO0O1qDbiDIfSbuK_WfdPf-co2eBP62jeAfYcdtNBtvcU7v13jJez2uOydh4ht5_Bl83sNvoXwJmLnI9gIz9FRbZsIL6bzFK0-fljNP2XLL4ur-eUyq_Jc6DQYy1WttJCKOulAcFtqqYocHCOOljWXleNaaKaEzscnXClXOKYUEbTkp-j8UDbN-nOAuDWtjxU0je2gH6KRUueSM_FfyCjNec5Zgq__gvf9ELr0B8MYEYzwYkRvD6gKfYwBarMJvrVhbygxYxompWHGNBJ9NdUbyhbcI5zWn8DZBGxMW6-D7SofHxyjJJesGAtlB7dLmez_2dAsvt5OjSfv4xZ-PXgbfhipuBLm2-eFuVkU1_PvN-_Nkv8BaNmtPA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220520392</pqid></control><display><type>article</type><title>The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Oda, Haruhiko ; Yamamoto, Yasuji ; Maeda, Kiyoshi</creator><creatorcontrib>Oda, Haruhiko ; Yamamoto, Yasuji ; Maeda, Kiyoshi</creatorcontrib><description>Objective
To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale––Revised (WAIS‐R) and the Wechsler Memory Scale––Revised (WMS‐R).
Design
We examined the WAIS‐R and the WMS‐R of 26 patients with probable DLB (based on the Consensus Criteria for the clinical diagnosis of DLB) and of 78 patients with probable Alzheimer's disease (AD) (based on criteria of the National Institute for Neurological and Communicative Disorders and Stroke‐Alzheimer's disease and Related Disorders Association) who were matched to the patients with DLB 3:1 by Mini‐Mental State Examination score.
Results
The DLB group scored significantly lower on the Block Design, Object Assembly and Digit Symbol of WAIS‐R and significantly higher on the Logical Memory I, Verbal Paired Associates I, Logical Memory II, Visual Paired Associates II, Verbal Paired Associates II and Visual Reproduction II of WMS‐R (p < 0.0016 to p < 0.0001). In a comparison between the DLB group and the AD group, a logistic regression analysis revealed that the weighted sum score of the Object Assembly and the Logical Memory II may differentiate DLB from AD with a sensitivity of 0.81 [95% Confidence Intervals (CI) = 0.66–0.96] and a specificity of 0.76 (95% CI = 0.66–0.85).
Conclusions
The WAIS‐R and the WMS‐R can help to differentiate DLB from AD. Copyright © 2008 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.2078</identifier><identifier>PMID: 18615776</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult and adolescent clinical studies ; Aged ; Aged, 80 and over ; Alzheimer disease ; Alzheimer Disease - diagnosis ; Alzheimer Disease - psychology ; Alzheimer's disease ; Biological and medical sciences ; Brain ; Cognition - classification ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia ; dementia with Lewy bodies ; Diagnosis, Differential ; Female ; Geriatric psychiatry ; Geriatric psychology ; Geriatrics ; Humans ; Lewy Bodies ; Lewy Body Disease - diagnosis ; Lewy Body Disease - psychology ; Male ; Medical sciences ; Memory ; Motor Skills ; Neurology ; Neuropsychological Tests ; Neuropsychology ; Older people ; Organic mental disorders. Neuropsychology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Regression Analysis ; Visual Perception</subject><ispartof>International journal of geriatric psychiatry, 2009-02, Vol.24 (2), p.125-131</ispartof><rights>Copyright © 2008 John Wiley & Sons, Ltd.</rights><rights>2009 INIST-CNRS</rights><rights>(c) 2008 John Wiley & Sons, Ltd.</rights><rights>Copyright John Wiley and Sons, Limited Feb 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4458-62247f785671d6de53ab86794ed20d1bf36cd3858275844458377d9d277051b3</citedby><cites>FETCH-LOGICAL-c4458-62247f785671d6de53ab86794ed20d1bf36cd3858275844458377d9d277051b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.2078$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.2078$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21046298$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18615776$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oda, Haruhiko</creatorcontrib><creatorcontrib>Yamamoto, Yasuji</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><title>The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Objective
To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale––Revised (WAIS‐R) and the Wechsler Memory Scale––Revised (WMS‐R).
Design
We examined the WAIS‐R and the WMS‐R of 26 patients with probable DLB (based on the Consensus Criteria for the clinical diagnosis of DLB) and of 78 patients with probable Alzheimer's disease (AD) (based on criteria of the National Institute for Neurological and Communicative Disorders and Stroke‐Alzheimer's disease and Related Disorders Association) who were matched to the patients with DLB 3:1 by Mini‐Mental State Examination score.
Results
The DLB group scored significantly lower on the Block Design, Object Assembly and Digit Symbol of WAIS‐R and significantly higher on the Logical Memory I, Verbal Paired Associates I, Logical Memory II, Visual Paired Associates II, Verbal Paired Associates II and Visual Reproduction II of WMS‐R (p < 0.0016 to p < 0.0001). In a comparison between the DLB group and the AD group, a logistic regression analysis revealed that the weighted sum score of the Object Assembly and the Logical Memory II may differentiate DLB from AD with a sensitivity of 0.81 [95% Confidence Intervals (CI) = 0.66–0.96] and a specificity of 0.76 (95% CI = 0.66–0.85).
Conclusions
The WAIS‐R and the WMS‐R can help to differentiate DLB from AD. Copyright © 2008 John Wiley & Sons, Ltd.</description><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer disease</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Cognition - classification</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia</subject><subject>dementia with Lewy bodies</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Geriatric psychiatry</subject><subject>Geriatric psychology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Lewy Bodies</subject><subject>Lewy Body Disease - diagnosis</subject><subject>Lewy Body Disease - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory</subject><subject>Motor Skills</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>Older people</subject><subject>Organic mental disorders. Neuropsychology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Regression Analysis</subject><subject>Visual Perception</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0VtrFDEUB_AgFrutgp9AgtDqy9RcJpd5LKuupYtauiD4EjKTM93UuazJDuv66c2wQwuC-JSH_HLOyfkj9JKSC0oIe3e3iReMKP0EzSgpioxSKZ-iGdFaZJJxcoxOYrwnJN1R_QwdUy2pUErO0O1qDbiDIfSbuK_WfdPf-co2eBP62jeAfYcdtNBtvcU7v13jJez2uOydh4ht5_Bl83sNvoXwJmLnI9gIz9FRbZsIL6bzFK0-fljNP2XLL4ur-eUyq_Jc6DQYy1WttJCKOulAcFtqqYocHCOOljWXleNaaKaEzscnXClXOKYUEbTkp-j8UDbN-nOAuDWtjxU0je2gH6KRUueSM_FfyCjNec5Zgq__gvf9ELr0B8MYEYzwYkRvD6gKfYwBarMJvrVhbygxYxompWHGNBJ9NdUbyhbcI5zWn8DZBGxMW6-D7SofHxyjJJesGAtlB7dLmez_2dAsvt5OjSfv4xZ-PXgbfhipuBLm2-eFuVkU1_PvN-_Nkv8BaNmtPA</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Oda, Haruhiko</creator><creator>Yamamoto, Yasuji</creator><creator>Maeda, Kiyoshi</creator><general>John Wiley & Sons, Ltd</general><general>Psychology Press</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease</title><author>Oda, Haruhiko ; Yamamoto, Yasuji ; Maeda, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4458-62247f785671d6de53ab86794ed20d1bf36cd3858275844458377d9d277051b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer disease</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>Biological and medical sciences</topic><topic>Brain</topic><topic>Cognition - classification</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia</topic><topic>dementia with Lewy bodies</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Geriatric psychiatry</topic><topic>Geriatric psychology</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Lewy Bodies</topic><topic>Lewy Body Disease - diagnosis</topic><topic>Lewy Body Disease - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory</topic><topic>Motor Skills</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>Older people</topic><topic>Organic mental disorders. Neuropsychology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Regression Analysis</topic><topic>Visual Perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oda, Haruhiko</creatorcontrib><creatorcontrib>Yamamoto, Yasuji</creatorcontrib><creatorcontrib>Maeda, Kiyoshi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oda, Haruhiko</au><au>Yamamoto, Yasuji</au><au>Maeda, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int. J. Geriat. Psychiatry</addtitle><date>2009-02</date><risdate>2009</risdate><volume>24</volume><issue>2</issue><spage>125</spage><epage>131</epage><pages>125-131</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objective
To demonstrate the exact nature of the cognitive profile of dementia with Lewy bodies (DLB) on standardized neuropsychological tests including the Wechsler Adult Intelligence Scale––Revised (WAIS‐R) and the Wechsler Memory Scale––Revised (WMS‐R).
Design
We examined the WAIS‐R and the WMS‐R of 26 patients with probable DLB (based on the Consensus Criteria for the clinical diagnosis of DLB) and of 78 patients with probable Alzheimer's disease (AD) (based on criteria of the National Institute for Neurological and Communicative Disorders and Stroke‐Alzheimer's disease and Related Disorders Association) who were matched to the patients with DLB 3:1 by Mini‐Mental State Examination score.
Results
The DLB group scored significantly lower on the Block Design, Object Assembly and Digit Symbol of WAIS‐R and significantly higher on the Logical Memory I, Verbal Paired Associates I, Logical Memory II, Visual Paired Associates II, Verbal Paired Associates II and Visual Reproduction II of WMS‐R (p < 0.0016 to p < 0.0001). In a comparison between the DLB group and the AD group, a logistic regression analysis revealed that the weighted sum score of the Object Assembly and the Logical Memory II may differentiate DLB from AD with a sensitivity of 0.81 [95% Confidence Intervals (CI) = 0.66–0.96] and a specificity of 0.76 (95% CI = 0.66–0.85).
Conclusions
The WAIS‐R and the WMS‐R can help to differentiate DLB from AD. Copyright © 2008 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>18615776</pmid><doi>10.1002/gps.2078</doi><tpages>7</tpages></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2009-02, Vol.24 (2), p.125-131 |
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| language | eng |
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| subjects | Adult and adolescent clinical studies Aged Aged, 80 and over Alzheimer disease Alzheimer Disease - diagnosis Alzheimer Disease - psychology Alzheimer's disease Biological and medical sciences Brain Cognition - classification Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia dementia with Lewy bodies Diagnosis, Differential Female Geriatric psychiatry Geriatric psychology Geriatrics Humans Lewy Bodies Lewy Body Disease - diagnosis Lewy Body Disease - psychology Male Medical sciences Memory Motor Skills Neurology Neuropsychological Tests Neuropsychology Older people Organic mental disorders. Neuropsychology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Regression Analysis Visual Perception |
| title | The neuropsychological profile in dementia with Lewy bodies and Alzheimer's disease |
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