Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine

Early postnatal maternal deprivation is known to cause long‐lasting neurobiological effects. Here, we investigated whether some of the cognitive aspects of these deficits might be related to a disruption of the cholinergic system. Pregnant Wistar rats were individually housed and maintained on a 12:...

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Veröffentlicht in:	International journal of developmental neuroscience 2009-02, Vol.27 (1), p.59-64
Hauptverfasser:	Benetti, Fernando, Mello, Pâmela Billig, Bonini, Juliana Sartori, Monteiro, Siomara, Cammarota, Martín, Izquierdo, Iván
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Acetylcholinesterase - analysis Acetylcholinesterase - metabolism Acetylcholinesterase activity Aging - physiology Animals Animals, Newborn Brain - drug effects Brain - growth & development Brain - physiopathology Disease Models, Animal Donepezil Female Galantamine Galantamine - pharmacology Hippocampus - drug effects Hippocampus - growth & development Hippocampus - physiopathology Indans - pharmacology Learning Disabilities - drug therapy Learning Disabilities - etiology Learning Disabilities - physiopathology Male Maternal Deprivation Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - physiopathology Neuropsychological Tests Nootropic Agents - pharmacology Object recognition Piperidines - pharmacology Rats Rats, Wistar Social Behavior Social recognition
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