IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice

We examined the role of hepatic interleukin (IL)-1α/β in serum total cholesterol homeostasis using male and female IL-1-knockout (KO) mice and wild-type (WT) mice. Serum total cholesterol level was higher in males than in females in WT and KO mice. The difference between sexes was closely correlated...

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