Engineering cell lines for production of replication defective HSV-1 gene therapy vectors

Herpes simplex virus type 1 (HSV-1) represents an attractive vehicle for a variety of gene therapy applications. To render this virus safe for clinical use, its cytotoxic genes must be removed without losing its ability to express transgenes efficiently. Our vectors are deleted for the essential imm...

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Veröffentlicht in:	Biotechnology and bioengineering 2009-03, Vol.102 (4), p.1087-1097
Hauptverfasser:	Grant, Kyle G, Krisky, David M, Ataai, Mohammed M, Glorioso, Joseph C. III
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Biotechnology - methods Cells Cercopithecus aethiops complementing cell line Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Gene Expression Regulation, Viral Gene therapy Genetic Therapy Genetic Vectors Genomics Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - growth & development HSV-1 Immediate-Early Proteins - genetics Studies Tissue engineering Vero Cells viral vector production Virus Replication
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