Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease
To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities. Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15,314) were analyzed. P...
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| Veröffentlicht in: | Pediatrics (Evanston) 2004-09, Vol.114 (3), p.751-754 |
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| creator | Muta, Hiromi Ishii, Masahiro Sakaue, Takahiko Egami, Kimiyasu Furui, Jun Sugahara, Yoko Akagi, Teiji Nakamura, Yoshikazu Yanagawa, Hiroshi Matsuishi, Toyojiro |
| description | To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities.
Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15,314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs).
The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous gamma-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous gamma-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46).
In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD. |
| doi_str_mv | 10.1542/peds.2003-0118-F |
| format | Article |
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Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15,314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs).
The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous gamma-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous gamma-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46).
In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2003-0118-F</identifier><identifier>PMID: 15342849</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Age ; Age Factors ; Aged ; Biological and medical sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Child ; Child, Preschool ; Clinical outcomes ; Elderly ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; General aspects ; Health aspects ; Humans ; Infant ; Kawasaki disease ; Kawasaki syndrome ; Male ; Malformations ; Medical sciences ; Mucocutaneous Lymph Node Syndrome - complications ; Pediatrics ; Risk Factors ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><ispartof>Pediatrics (Evanston), 2004-09, Vol.114 (3), p.751-754</ispartof><rights>2004 INIST-CNRS</rights><rights>COPYRIGHT 2004 American Academy of Pediatrics</rights><rights>COPYRIGHT 2004 American Academy of Pediatrics</rights><rights>Copyright American Academy of Pediatrics Sep 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c608t-d82f09c64fc1d7279b509b80f3475c919420ec459304b44187a8ac192420cc2a3</citedby><cites>FETCH-LOGICAL-c608t-d82f09c64fc1d7279b509b80f3475c919420ec459304b44187a8ac192420cc2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16086663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15342849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muta, Hiromi</creatorcontrib><creatorcontrib>Ishii, Masahiro</creatorcontrib><creatorcontrib>Sakaue, Takahiko</creatorcontrib><creatorcontrib>Egami, Kimiyasu</creatorcontrib><creatorcontrib>Furui, Jun</creatorcontrib><creatorcontrib>Sugahara, Yoko</creatorcontrib><creatorcontrib>Akagi, Teiji</creatorcontrib><creatorcontrib>Nakamura, Yoshikazu</creatorcontrib><creatorcontrib>Yanagawa, Hiroshi</creatorcontrib><creatorcontrib>Matsuishi, Toyojiro</creatorcontrib><title>Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities.
Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15,314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs).
The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous gamma-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous gamma-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46).
In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.</description><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical outcomes</subject><subject>Elderly</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>General aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infant</subject><subject>Kawasaki disease</subject><subject>Kawasaki syndrome</subject><subject>Male</subject><subject>Malformations</subject><subject>Medical sciences</subject><subject>Mucocutaneous Lymph Node Syndrome - complications</subject><subject>Pediatrics</subject><subject>Risk Factors</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkt2LEzEUxQdR3HX13ScJgoIPU5NMZiZ5LF27LhYKfjxKuM3cmWY3ndRkZlf_e1NaqJUSQsLN7ySXk5NlrxmdsFLwj1ts4oRTWuSUMZnPn2SXjCqZC16XT7PLdMByQWl5kb2I8Y5SKsqaP88uWFkILoW6zH4uXYOBTDskt5EA-WrjPZmDGXwgbZrDGsk1PqDz2w32A_EtmUForH-AaEYHgXzDXyM6QGJ78gUeIcK9Jdc2IkR8mT1rwUV8dVivsh_zT99nn_PF8uZ2Nl3kpqJyyBvJW6pMJVrDmprXalVStZK0LURdGsWU4BSNKFVBxUoIJmuQYJjiqW4Mh-Iqe7-_dxt86iYOemOjQeegRz9GXVUy2cBUAt_-B975MfSpN825LCRLWILyPdSBQ2371g8BTIc9BnC-x9am8pRxnjqRSiZ-coZPo8GNNWcFH04EiRnw99DBGKOWN4tTNj_HGu8cdqiTjbPlKU_3vAk-xoCt3ga7gfBHM6p3odG70OhdaPQuNHqeJG8OpoyrDTZHwSElCXh3ANKng2sD9MbGI5c-saqq4mjE2nbrRxtw95aFIVgT_9kyJnSh65IVfwEJ8tXO</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Muta, Hiromi</creator><creator>Ishii, Masahiro</creator><creator>Sakaue, Takahiko</creator><creator>Egami, Kimiyasu</creator><creator>Furui, Jun</creator><creator>Sugahara, Yoko</creator><creator>Akagi, Teiji</creator><creator>Nakamura, Yoshikazu</creator><creator>Yanagawa, Hiroshi</creator><creator>Matsuishi, Toyojiro</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20040901</creationdate><title>Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease</title><author>Muta, Hiromi ; Ishii, Masahiro ; Sakaue, Takahiko ; Egami, Kimiyasu ; Furui, Jun ; Sugahara, Yoko ; Akagi, Teiji ; Nakamura, Yoshikazu ; Yanagawa, Hiroshi ; Matsuishi, Toyojiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c608t-d82f09c64fc1d7279b509b80f3475c919420ec459304b44187a8ac192420cc2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical outcomes</topic><topic>Elderly</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>General aspects</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infant</topic><topic>Kawasaki disease</topic><topic>Kawasaki syndrome</topic><topic>Male</topic><topic>Malformations</topic><topic>Medical sciences</topic><topic>Mucocutaneous Lymph Node Syndrome - complications</topic><topic>Pediatrics</topic><topic>Risk Factors</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muta, Hiromi</creatorcontrib><creatorcontrib>Ishii, Masahiro</creatorcontrib><creatorcontrib>Sakaue, Takahiko</creatorcontrib><creatorcontrib>Egami, Kimiyasu</creatorcontrib><creatorcontrib>Furui, Jun</creatorcontrib><creatorcontrib>Sugahara, Yoko</creatorcontrib><creatorcontrib>Akagi, Teiji</creatorcontrib><creatorcontrib>Nakamura, Yoshikazu</creatorcontrib><creatorcontrib>Yanagawa, Hiroshi</creatorcontrib><creatorcontrib>Matsuishi, Toyojiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muta, Hiromi</au><au>Ishii, Masahiro</au><au>Sakaue, Takahiko</au><au>Egami, Kimiyasu</au><au>Furui, Jun</au><au>Sugahara, Yoko</au><au>Akagi, Teiji</au><au>Nakamura, Yoshikazu</au><au>Yanagawa, Hiroshi</au><au>Matsuishi, Toyojiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>114</volume><issue>3</issue><spage>751</spage><epage>754</epage><pages>751-754</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>To clarify the characteristics of Kawasaki disease (KD) in children 6 years and older and to determine whether age is a risk factor for cardiovascular abnormalities.
Patients who had KD and were reported between 1999 and 2000 in the 16th nationwide survey of KD in Japan (n = 15,314) were analyzed. Patients who were aged 6 years or older (older group) were matched with patients who were aged 6 months to 3 years and were treated at the same hospital (younger groups). The total number of analyzed patients was 1498 (749 matched pairs).
The proportion of complete KD in the older group was similar to that in the younger group. Recurrent cases in the older group were significantly more common than those in the younger group (9% vs 2%). The proportion of patients who were treated with intravenous gamma-globulin in the older group was significantly lower than that in the younger group (82% vs 87%). The proportion of older group patients who were treated with intravenous gamma-globulin at or after 7 days of illness was significantly higher than that in the younger group (35% vs 14%). There was a higher prevalence of cardiovascular abnormalities in the older group than in the younger group (20% vs 15%). Multivariate logistic regression analysis showed that older age was an independent risk factor for cardiovascular sequelae (odds ratio: 1.58; 95% confidence interval: 1.01-2.46).
In children older than 6 years, age is an independent risk factor for cardiovascular sequelae in KD.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>15342849</pmid><doi>10.1542/peds.2003-0118-F</doi><tpages>4</tpages></addata></record> |
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| subjects | Age Age Factors Aged Biological and medical sciences Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - etiology Child Child, Preschool Clinical outcomes Elderly Female Gastroenterology. Liver. Pancreas. Abdomen General aspects Health aspects Humans Infant Kawasaki disease Kawasaki syndrome Male Malformations Medical sciences Mucocutaneous Lymph Node Syndrome - complications Pediatrics Risk Factors Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus |
| title | Older Age Is a Risk Factor for the Development of Cardiovascular Sequelae in Kawasaki Disease |
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