Effect of long-term and high-dose antithrombin supplementation on coagulation and fibrinolysis in patients with severe sepsis

OBJECTIVE:Sepsis is frequently associated with coagulatory activation, which may contribute to deteriorated organ function. Antithrombin is one important endogenous coagulation inhibitor that is therapeutically applied during sepsis. This study investigates the effect of 14-day antithrombin applicat...

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Veröffentlicht in:	Critical care medicine 2004-09, Vol.32 (9), p.1851-1859
Hauptverfasser:	Hoffmann, Johannes N, Mühlbayer, Dieter, Jochum, Marianne, Inthorn, Dietrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antithrombin III - administration & dosage Antithrombin III - pharmacology Biological and medical sciences Blood Coagulation - drug effects Blood Coagulation Tests Disseminated Intravascular Coagulation - etiology Disseminated Intravascular Coagulation - prevention & control Female Fibrinolysis - drug effects Germany - epidemiology Humans Intensive care medicine Male Medical sciences Middle Aged Prospective Studies Protein C - drug effects Sepsis - complications Sepsis - drug therapy Sepsis - mortality Serine Proteinase Inhibitors - administration & dosage Serine Proteinase Inhibitors - pharmacology
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