Increased Bioavailability of Tacrolimus after Rectal Administration in Rats

The oral bioavailability of tacrolimus is low and varies considerably in humans due to first-pass metabolism by cytochrome P450 (CYP) 3A4 and the active efflux mediated by P-glycoprotein. This study was undertaken to elucidate the usefulness of rectal administration of tacrolimus as an alternative r...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2004, Vol.27(9), pp.1480-1482
Hauptverfasser:	Sakai, Masayuki, Hobara, Norio, Hokama, Nobuo, Kameya, Hiromasa, Ohshiro, Susumu, Sakanashi, Matao, Saitoh, Hiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Administration, Rectal Animals Area Under Curve bioavailability Biological Availability blood concentration first-pass metabolism Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - blood Immunosuppressive Agents - pharmacokinetics Male Rats Rats, Sprague-Dawley rectal administration Suppositories tacrolimus Tacrolimus - administration & dosage Tacrolimus - blood Tacrolimus - pharmacokinetics
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