B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells

Autoimmune diseases are marked by the presence of class-switched, high-affinity autoantibodies with pathogenic potential. Costimulation plays an important role in the activation of T cells and the development of T cell-dependent B cell responses. ICOS plays an indispensable role in the development o...

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Veröffentlicht in:	The Journal of immunology (1950) 2009-02, Vol.182 (3), p.1421-1428
Hauptverfasser:	Hu, Yi-Ling, Metz, Daniela P, Chung, James, Siu, Gerald, Zhang, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Blocking - administration & dosage Antibodies, Monoclonal - administration & dosage Antigens, Differentiation, T-Lymphocyte - immunology Antigens, Differentiation, T-Lymphocyte - physiology Arthritis, Experimental - immunology Arthritis, Experimental - pathology Arthritis, Experimental - therapy Autoantibodies - biosynthesis Autoantibodies - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism B-Lymphocytes - pathology B7-1 Antigen - immunology B7-1 Antigen - physiology Cell Differentiation - immunology Female Germinal Center - immunology Germinal Center - metabolism Germinal Center - pathology Inducible T-Cell Co-Stimulator Ligand Inducible T-Cell Co-Stimulator Protein Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lupus Erythematosus, Systemic - therapy Lymphocyte Activation - immunology Male Mice Mice, Inbred BALB C Mice, Inbred DBA Mice, Inbred NZB Random Allocation Signal Transduction - immunology T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - pathology
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