Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue
Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidatio...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2009-02, Vol.379 (2), p.605-609 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Sakurai, Takuya Izawa, Tetsuya Kizaki, Takako Ogasawara, Jun-etsu Shirato, Ken Imaizumi, Kazuhiko Takahashi, Kazuto Ishida, Hitoshi Ohno, Hideki |
| description | Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT. |
| doi_str_mv | 10.1016/j.bbrc.2008.12.127 |
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We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2008.12.127</identifier><identifier>PMID: 19121629</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipokines - biosynthesis ; Adipose Tissue, White - metabolism ; Animals ; Exercise training ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Inflammation - metabolism ; Inflammation-related adipokines ; Lipid Peroxidation ; Male ; Membrane Glycoproteins - biosynthesis ; NADPH oxidase ; NADPH Oxidase 2 ; NADPH Oxidases - biosynthesis ; Oxidative stress ; Oxidative Stress - physiology ; Physical Conditioning, Animal ; Rats ; Rats, Wistar ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; White adipose tissue</subject><ispartof>Biochemical and biophysical research communications, 2009-02, Vol.379 (2), p.605-609</ispartof><rights>2008 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-3688c9903a35ff1cb68ae3310ba2455a8b2ecb01892c25f10a2e08ec3925df5e3</citedby><cites>FETCH-LOGICAL-c451t-3688c9903a35ff1cb68ae3310ba2455a8b2ecb01892c25f10a2e08ec3925df5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2008.12.127$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19121629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sakurai, Takuya</creatorcontrib><creatorcontrib>Izawa, Tetsuya</creatorcontrib><creatorcontrib>Kizaki, Takako</creatorcontrib><creatorcontrib>Ogasawara, Jun-etsu</creatorcontrib><creatorcontrib>Shirato, Ken</creatorcontrib><creatorcontrib>Imaizumi, Kazuhiko</creatorcontrib><creatorcontrib>Takahashi, Kazuto</creatorcontrib><creatorcontrib>Ishida, Hitoshi</creatorcontrib><creatorcontrib>Ohno, Hideki</creatorcontrib><title>Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.</description><subject>Adipokines - biosynthesis</subject><subject>Adipose Tissue, White - metabolism</subject><subject>Animals</subject><subject>Exercise training</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Inflammation - metabolism</subject><subject>Inflammation-related adipokines</subject><subject>Lipid Peroxidation</subject><subject>Male</subject><subject>Membrane Glycoproteins - biosynthesis</subject><subject>NADPH oxidase</subject><subject>NADPH Oxidase 2</subject><subject>NADPH Oxidases - biosynthesis</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Physical Conditioning, Animal</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>White adipose tissue</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2LFDEQhoMo7uzqH_AgOXnrsSrpZNPgRZbVFRa8KHgL6aR6J2N_jEl6HX-Df9puZsCbQkEoeN6nIC9jrxC2CKjf7rdtm_xWAJgtimWun7ANQgOVQKifsg0A6Eo0-O2CXea8B0CsdfOcXWCDArVoNuz37ZGSj5l4SS6OcXzggXwilylzOh4S5RynkU8dj2PXu2FwZdmrRL0rFLgL8TB9j-NCl12a5ocdTxRmX86h6RjDkngknsvqWiw8ucJ_7mKhU3q9HXOe6QV71rk-08vze8W-frj9cnNX3X_--Onm_X3la4WlktoY3zQgnVRdh77VxpGUCK0TtVLOtIJ8C2ga4YXqEJwgMORlI1ToFMkr9ubkPaTpx0y52CFmT33vRprmbLU20mh1_V9QgFBC1nIBxQn0aco5UWcPKQ4u_bIIdu3K7u3alV27siiWWe2vz_a5HSj8jZzLWYB3J4CWz3iMlGz2kUZPISbyxYYp_sv_B3dcqRc</recordid><startdate>20090206</startdate><enddate>20090206</enddate><creator>Sakurai, Takuya</creator><creator>Izawa, Tetsuya</creator><creator>Kizaki, Takako</creator><creator>Ogasawara, Jun-etsu</creator><creator>Shirato, Ken</creator><creator>Imaizumi, Kazuhiko</creator><creator>Takahashi, Kazuto</creator><creator>Ishida, Hitoshi</creator><creator>Ohno, Hideki</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TS</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20090206</creationdate><title>Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue</title><author>Sakurai, Takuya ; Izawa, Tetsuya ; Kizaki, Takako ; Ogasawara, Jun-etsu ; Shirato, Ken ; Imaizumi, Kazuhiko ; Takahashi, Kazuto ; Ishida, Hitoshi ; Ohno, Hideki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-3688c9903a35ff1cb68ae3310ba2455a8b2ecb01892c25f10a2e08ec3925df5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipokines - biosynthesis</topic><topic>Adipose Tissue, White - metabolism</topic><topic>Animals</topic><topic>Exercise training</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Inflammation - metabolism</topic><topic>Inflammation-related adipokines</topic><topic>Lipid Peroxidation</topic><topic>Male</topic><topic>Membrane Glycoproteins - biosynthesis</topic><topic>NADPH oxidase</topic><topic>NADPH Oxidase 2</topic><topic>NADPH Oxidases - biosynthesis</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Physical Conditioning, Animal</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>White adipose tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakurai, Takuya</creatorcontrib><creatorcontrib>Izawa, Tetsuya</creatorcontrib><creatorcontrib>Kizaki, Takako</creatorcontrib><creatorcontrib>Ogasawara, Jun-etsu</creatorcontrib><creatorcontrib>Shirato, Ken</creatorcontrib><creatorcontrib>Imaizumi, Kazuhiko</creatorcontrib><creatorcontrib>Takahashi, Kazuto</creatorcontrib><creatorcontrib>Ishida, Hitoshi</creatorcontrib><creatorcontrib>Ohno, Hideki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Physical Education Index</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakurai, Takuya</au><au>Izawa, Tetsuya</au><au>Kizaki, Takako</au><au>Ogasawara, Jun-etsu</au><au>Shirato, Ken</au><au>Imaizumi, Kazuhiko</au><au>Takahashi, Kazuto</au><au>Ishida, Hitoshi</au><au>Ohno, Hideki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2009-02-06</date><risdate>2009</risdate><volume>379</volume><issue>2</issue><spage>605</spage><epage>609</epage><pages>605-609</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-α and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>19121629</pmid><doi>10.1016/j.bbrc.2008.12.127</doi><tpages>5</tpages></addata></record> |
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| subjects | Adipokines - biosynthesis Adipose Tissue, White - metabolism Animals Exercise training Extracellular Signal-Regulated MAP Kinases - metabolism Inflammation - metabolism Inflammation-related adipokines Lipid Peroxidation Male Membrane Glycoproteins - biosynthesis NADPH oxidase NADPH Oxidase 2 NADPH Oxidases - biosynthesis Oxidative stress Oxidative Stress - physiology Physical Conditioning, Animal Rats Rats, Wistar Superoxide dismutase Superoxide Dismutase - metabolism White adipose tissue |
| title | Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue |
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