Susceptibility of hepatitis B virus to lamivudine restored by resistance to adefovir

Serial monotherapy and add-on regimes for treatment of chronic hepatitis B virus (HBV) infection may induce the accumulation of viral resistance mutations in patients, reducing the options for ongoing viral suppression. The induction of antiviral resistance by serial application of polymerase inhibi...

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Veröffentlicht in:	Journal of medical virology 2009-03, Vol.81 (3), p.413-416
Hauptverfasser:	Zaaijer, H.L, Takkenberg, R.B, Weegink, C.J, Rebers, S.P.H, Menting, S, Reesink, H.W, Schinkel, J, Molenkamp, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Adenine - therapeutic use Adult Amino Acid Substitution Antiviral Agents - pharmacology Antiviral Agents - therapeutic use antiviral therapy Biological and medical sciences DNA Mutational Analysis DNA, Viral - genetics Drug Resistance, Viral Drug Therapy, Combination Fundamental and applied biological sciences. Psychology HBV Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Human immunodeficiency virus Human viral diseases Humans Infectious diseases Lamivudine - pharmacology Lamivudine - therapeutic use Male Medical sciences Microbiology Miscellaneous mutation Mutation, Missense Organophosphonates - pharmacology Organophosphonates - therapeutic use Sequence Analysis, DNA subpopulation Viral diseases Viral Load Virology
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