Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose

We examined the expression of the major H 2S-producing enzymes, cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE). CBS was ubiquitously distributed in the mouse pancreas, but CSE was found only in the exocrine. Freshly isolated islets expressed CBS, while CSE was faint. However, high gl...

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Veröffentlicht in:	FEBS letters 2009-01, Vol.583 (2), p.377-382
Hauptverfasser:	Kaneko, Yukiko, Kimura, Toshihide, Taniguchi, Shigeki, Souma, Midori, Kojima, Yumiko, Kimura, Yuka, Kimura, Hideo, Niki, Ichiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Cystathionine beta-Synthase - biosynthesis Cystathionine gamma-Lyase - biosynthesis Cystathionine-β-synthase (CBS) Cystathionine-γ-lyase (CSE) Cysteine - pharmacology Glucose - metabolism Glucose - pharmacology Hydrogen sulfide Hydrogen Sulfide - metabolism Insulin-Secreting Cells - cytology Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - enzymology l-Cysteine Mice Pancreatic beta-cell Sulfides - pharmacology
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