Gene loops juxtapose promoters and terminators in yeast

Mechanistic analysis of transcriptional initiation and termination by RNA polymerase II (PolII) indicates that some factors are common to both processes. Here we show that two long genes of Saccharomyces cerevisiae, FMP27 and SEN1, exist in a looped conformation, effectively bringing together their...

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Veröffentlicht in:	Nature genetics 2004-09, Vol.36 (9), p.1014-1018
Hauptverfasser:	Proudfoot, Nick J, O'Sullivan, Justin M, Tan-Wong, Sue Mei, Morillon, Antonin, Lee, Barbara, Coles, Joel, Mellor, Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Biomedicine Brewer's yeast Cancer Research DNA Helicases Fungal Proteins - chemistry Fungal Proteins - genetics Gene Function Genetic aspects Human Genetics Inactivation letter Models, Genetic Nucleic Acid Conformation Open Reading Frames Phosphorylation Physiological aspects Polymerase chain reaction Promoter Regions, Genetic Promoters (Genetics) RNA Helicases RNA Polymerase II - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Terminator Regions, Genetic Transcription, Genetic Yeasts
Online-Zugang:	Volltext
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