In situ analyses of genome instability in breast cancer
Transition through telomere crisis is thought to be a crucial event in the development of most breast carcinomas. Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluoresce...
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| Veröffentlicht in: | Nature genetics 2004-09, Vol.36 (9), p.984-988 |
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| creator | Gray, Joe W Chin, Koei de Solorzano, Carlos Ortiz Knowles, David Jones, Arthur Chou, William Rodriguez, Enrique Garcia Kuo, Wen-Lin Ljung, Britt-Marie Chew, Karen Myambo, Kenneth Miranda, Monica Krig, Sheryl Garbe, James Stampfer, Martha Yaswen, Paul Lockett, Stephen J |
| description | Transition through telomere crisis is thought to be a crucial event in the development of most breast carcinomas. Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ. |
| doi_str_mv | 10.1038/ng1409 |
| format | Article |
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Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng1409</identifier><identifier>PMID: 15300252</identifier><language>eng</language><publisher>United States: Nature Publishing Group</publisher><subject>Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - pathology ; Carcinoma, Intraductal, Noninfiltrating - genetics ; Carcinoma, Intraductal, Noninfiltrating - pathology ; Chromosomal Instability ; Control ; Crises ; Development and progression ; Disease Progression ; Fluorescence ; Gene mutations ; Genetic aspects ; Health aspects ; Humans ; Hybridization ; Hyperplasia - genetics ; Hyperplasia - pathology ; In Situ Hybridization ; Telomere - diagnostic imaging ; Tumor Cells, Cultured ; Ultrasonography</subject><ispartof>Nature genetics, 2004-09, Vol.36 (9), p.984-988</ispartof><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-b701033ef8537ed578d9ad46bd76b2f59b6db7f3c8d882fabd15431b217b4b563</citedby><cites>FETCH-LOGICAL-c521t-b701033ef8537ed578d9ad46bd76b2f59b6db7f3c8d882fabd15431b217b4b563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2728,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15300252$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gray, Joe W</creatorcontrib><creatorcontrib>Chin, Koei</creatorcontrib><creatorcontrib>de Solorzano, Carlos Ortiz</creatorcontrib><creatorcontrib>Knowles, David</creatorcontrib><creatorcontrib>Jones, Arthur</creatorcontrib><creatorcontrib>Chou, William</creatorcontrib><creatorcontrib>Rodriguez, Enrique Garcia</creatorcontrib><creatorcontrib>Kuo, Wen-Lin</creatorcontrib><creatorcontrib>Ljung, Britt-Marie</creatorcontrib><creatorcontrib>Chew, Karen</creatorcontrib><creatorcontrib>Myambo, Kenneth</creatorcontrib><creatorcontrib>Miranda, Monica</creatorcontrib><creatorcontrib>Krig, Sheryl</creatorcontrib><creatorcontrib>Garbe, James</creatorcontrib><creatorcontrib>Stampfer, Martha</creatorcontrib><creatorcontrib>Yaswen, Paul</creatorcontrib><creatorcontrib>Lockett, Stephen J</creatorcontrib><title>In situ analyses of genome instability in breast cancer</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><description>Transition through telomere crisis is thought to be a crucial event in the development of most breast carcinomas. Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ.</description><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - pathology</subject><subject>Carcinoma, Ductal, Breast - genetics</subject><subject>Carcinoma, Ductal, Breast - pathology</subject><subject>Carcinoma, Intraductal, Noninfiltrating - genetics</subject><subject>Carcinoma, Intraductal, Noninfiltrating - pathology</subject><subject>Chromosomal Instability</subject><subject>Control</subject><subject>Crises</subject><subject>Development and progression</subject><subject>Disease Progression</subject><subject>Fluorescence</subject><subject>Gene mutations</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hybridization</subject><subject>Hyperplasia - genetics</subject><subject>Hyperplasia - pathology</subject><subject>In Situ Hybridization</subject><subject>Telomere - diagnostic imaging</subject><subject>Tumor Cells, 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Our goal in this study was to determine where this occurs in the context of histologically defined breast cancer progression. To this end, we assessed genome instability (using fluorescence in situ hybridization) and other features associated with telomere crisis in normal ductal epithelium, usual ductal hyperplasia, ductal carcinoma in situ and invasive cancer. We modeled this process in vitro by measuring these same features in human mammary epithelial cell cultures during ZNF217-mediated transition through telomere crisis and immortalization. Taken together, the data suggest that transition through telomere crisis and immortalization in breast cancer occurs during progression from usual ductal hyperplasia to ductal carcinoma in situ.</abstract><cop>United States</cop><pub>Nature Publishing Group</pub><pmid>15300252</pmid><doi>10.1038/ng1409</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Chromosomal Instability Control Crises Development and progression Disease Progression Fluorescence Gene mutations Genetic aspects Health aspects Humans Hybridization Hyperplasia - genetics Hyperplasia - pathology In Situ Hybridization Telomere - diagnostic imaging Tumor Cells, Cultured Ultrasonography |
| title | In situ analyses of genome instability in breast cancer |
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