Crystal engineering of the composition of pharmaceutical phases. Do pharmaceutical co-crystals represent a new path to improved medicines?

The evolution of crystal engineering into a form of supramolecular synthesis is discussed in the context of problems and opportunities in the pharmaceutical industry. Specifically, it has become clear that a wide array of multiple component pharmaceutical phases, so called pharmaceutical co-crystals...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2004-09 (17), p.1889-1896
Hauptverfasser:	Almarsson, Orn, Zaworotko, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids - chemistry Amides - chemistry Carboxylic Acids - chemistry Chemistry, Pharmaceutical - methods Crystallization - methods Crystallography Drug Stability Hydrogen Bonding Molecular Structure Organic Chemicals - chemistry Pharmaceutical Preparations Phase Transition Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods
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