Multiple‐Testing Strategy for Analyzing cDNA Array Data on Gene Expression

An objective of many functional genomics studies is to estimate treatment‐induced changes in gene expression. cDNA arrays interrogate each tissue sample for the levels of mRNA for hundreds to tens of thousands of genes, and the use of this technology leads to a multitude of treatment contrasts. By‐g...

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Veröffentlicht in:	Biometrics 2004-09, Vol.60 (3), p.774-782
Hauptverfasser:	Delongchamp, Robert R., Bowyer, John F., Chen, James J., Kodell, Ralph L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Animals Biometrics Biometry Brain - drug effects Brain - metabolism Complementary DNA Consultant's Forum Data Interpretation, Statistical Decision theory Deoxyribonucleic acid DNA Fall lines False discovery rate False negative errors False nondiscovery rate False positive errors Gene expression Gene Expression - drug effects Gene Expression Profiling - statistics & numerical data gene expression regulation Genes Genomics Genomics - statistics & numerical data messenger RNA Models, Statistical Null hypothesis Oligonucleotide Array Sequence Analysis - statistics & numerical data P values p-value plot Rats ROC Curve ROC curves Statistical variance Subset selection
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