The effects of deleterious mutations on evolution in non-recombining genomes
Analyzing regions of the Drosophila genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes...
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| Veröffentlicht in: | Trends in genetics 2009-01, Vol.25 (1), p.9-12 |
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| creator | Kaiser, Vera B Charlesworth, Brian |
| description | Analyzing regions of the Drosophila genome that have low levels of genetic recombination helps us understand the prevalence of sexual reproduction. Here, we show that genetic variability in these regions can be explained by interference among strongly deleterious mutations and that selection becomes progressively less effective in influencing the behaviour of neighbouring sites as the number of closely linked sites on a chromosome increases. |
| doi_str_mv | 10.1016/j.tig.2008.10.009 |
| format | Article |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Biological evolution Drosophila Drosophila - genetics Evolution, Molecular Female Fundamental and applied biological sciences. Psychology Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome, Insect Male Medical Education Models, Genetic Molecular and cellular biology Mutation Recombination, Genetic Reproduction - genetics |
| title | The effects of deleterious mutations on evolution in non-recombining genomes |
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