Nuclear and Mitochondrial Genome Defects in Autisms

In this review we will evaluate evidence that altered gene dosage and structure impacts neurodevelopment and neural connectivity through deleterious effects on synaptic structure and function, and evidence that the latter are key contributors to the risk for autism. We will review information on alt...

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Veröffentlicht in:	Annals of the New York Academy of Sciences 2009-01, Vol.1151 (1), p.102-132
Hauptverfasser:	Smith, Moyra, Spence, M. Anne, Flodman, Pamela
Format:	Artikel
Sprache:	eng
Schlagworte:	autism Autistic Disorder - diagnosis Autistic Disorder - genetics Autistic Disorder - metabolism Cell Nucleus - genetics copy number (CN) copy number variation (CNV) DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism dosage changes genome Genome, Human Genome, Mitochondrial - genetics Humans Microarray Analysis - methods mitochondria Nuclear Proteins - genetics Nuclear Proteins - metabolism twins
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