Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection

Human mannose-binding protein (MBL) is a component of innate immunity. To capture the common genetic variants of MBL2 , we resequenced a 10.0 kb region that includes MBL2 in 102 individuals representing four major US ethnic groups. In all, 87 polymorphic sites were observed, indicating a high level...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes and immunity 2004-09, Vol.5 (6), p.461-476
Hauptverfasser:	Bernig, T, Taylor, J G, Foster, C B, Staats, B, Yeager, M, Chanock, S J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Autoimmune diseases Binding proteins Biomedical and Life Sciences Biomedicine Cancer Cancer Research Ethnic Groups full-paper Gene conversion Gene Expression Gene Frequency Genes Genetic diversity Genetic Variation Haplotypes Haplotypes - genetics Heterozygosity Human Genetics Humans Immune response Immunology Infections Innate immunity Lectins Linkage Disequilibrium Loss of Heterozygosity Mannose Mannose-binding lectin Mannose-Binding Lectin - analogs & derivatives Mannose-Binding Lectin - genetics Microorganisms Minority & ethnic groups Oncology Pathogens Pediatrics Phylogeny Polymorphism, Single Nucleotide Population genetics Recombination Recombination hot spots Regulation Selection, Genetic Sequence analysis Sequence Analysis, DNA Single-nucleotide polymorphism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!