Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists
Summary Background : The attenuated anti‐secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether Helicobacter pylori infection affects the occurrence of tolerance to H2RA. It is also not cl...
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| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2004-09, Vol.20 (5), p.559-565 |
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| container_title | Alimentary pharmacology & therapeutics |
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| creator | Fujisawa, T. Adachi, K. Komazawa, Y. Mihara, T. Azumi, T. Katsube, T. Furuta, K. Kazumori, H. Kinoshita, Y. |
| description | Summary
Background : The attenuated anti‐secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether Helicobacter pylori infection affects the occurrence of tolerance to H2RA. It is also not clarified whether the tolerance phenomenon occurs to a new H2RA, lafutidine.
Aim : To investigate the occurrence of the tolerance phenomenon in subjects with and without H. pylori infection during the continuous administration of lafutidine and famotidine.
Subjects and Methods : Subjects were 20 healthy male volunteers (seven H. pylori positive and 13 H. pylori negative cases). All subjects were examined by ambulatory intragastric pH monitoring five times without medication, on the first and 15th day of the administration of 20 mg b.d. famotidine and 10 mg b.d. lafutidine in a cross‐over fashion.
Results : The tolerance phenomenon was not observed in H. pylori‐positive subjects during the 15‐day‐long administration of both H2RAs. In contrast, the tolerance phenomenon was observed in H. pylori negative subjects, which has been previously reported.
Conclusions : This study demonstrated that H. pylori infection affects the tolerance phenomenon during continuous administration of H2RAs. |
| doi_str_mv | 10.1111/j.1365-2036.2004.02147.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66833766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>66833766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4617-4bfc0e9c00ec99740209514a22dbd2cdb161cb003d28570b0bc4862fa0df0c9a3</originalsourceid><addsrcrecordid>eNqNkMFu3CAQhlHUKtmkfYWKS3uzO4AX24ceoqjtRoqUHNIzwuNxl5UNLniT7NvXzq6aa5EQo_m_AfQxxgXkYl5fd7lQep1JUDqXAEUOUhRl_nLGVv-Cd2wFUteZrIS6YJcp7QBAlyDP2YVYK1UrWa7Y04Z6h6GxOFHk46EP0XHnO8LJBc_HSE_kp8SnLfGAuI-RPM5l99qZQk_RLo1xSz4M8_ZLtnVpsoPzxDeSR0IapxC59ZP9HfycpQ_sfWf7RB9P5xX79eP7480mu7v_eXtzfZdhoUWZFU2HQDUCENZ1WYCEei0KK2XbtBLbRmiBDYBqZbUuoYEGi0rLzkLbAdZWXbEvx3vHGP7sKU1mcAmp762nsE9G60qpUusZrI4gxpBSpM6M0Q02HowAszg3O7OoNYtaszg3r87Nyzz66fTGvhmofRs8SZ6BzyfAJrR9txhz6Y3TUFWgxcx9O3LPrqfDf3_AXD88LpX6C33Znxs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>66833766</pqid></control><display><type>article</type><title>Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists</title><source>Wiley Free Content</source><source>MEDLINE</source><source>IngentaConnect Free/Open Access Journals</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Fujisawa, T. ; Adachi, K. ; Komazawa, Y. ; Mihara, T. ; Azumi, T. ; Katsube, T. ; Furuta, K. ; Kazumori, H. ; Kinoshita, Y.</creator><creatorcontrib>Fujisawa, T. ; Adachi, K. ; Komazawa, Y. ; Mihara, T. ; Azumi, T. ; Katsube, T. ; Furuta, K. ; Kazumori, H. ; Kinoshita, Y.</creatorcontrib><description>Summary
Background : The attenuated anti‐secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether Helicobacter pylori infection affects the occurrence of tolerance to H2RA. It is also not clarified whether the tolerance phenomenon occurs to a new H2RA, lafutidine.
Aim : To investigate the occurrence of the tolerance phenomenon in subjects with and without H. pylori infection during the continuous administration of lafutidine and famotidine.
Subjects and Methods : Subjects were 20 healthy male volunteers (seven H. pylori positive and 13 H. pylori negative cases). All subjects were examined by ambulatory intragastric pH monitoring five times without medication, on the first and 15th day of the administration of 20 mg b.d. famotidine and 10 mg b.d. lafutidine in a cross‐over fashion.
Results : The tolerance phenomenon was not observed in H. pylori‐positive subjects during the 15‐day‐long administration of both H2RAs. In contrast, the tolerance phenomenon was observed in H. pylori negative subjects, which has been previously reported.
Conclusions : This study demonstrated that H. pylori infection affects the tolerance phenomenon during continuous administration of H2RAs.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2004.02147.x</identifier><identifier>PMID: 15339327</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Acetamides - administration & dosage ; Adult ; Ambulatory Care ; Biological and medical sciences ; Circadian Rhythm ; Cross-Over Studies ; Cross-Sectional Studies ; Digestive system ; Drug Tolerance - physiology ; Famotidine - administration & dosage ; Gastroenterology. Liver. Pancreas. Abdomen ; Helicobacter Infections - physiopathology ; Helicobacter pylori ; Histamine H2 Antagonists - administration & dosage ; Humans ; Hydrogen-Ion Concentration ; Male ; Medical sciences ; Middle Aged ; Pharmacology. Drug treatments ; Piperidines - administration & dosage ; Pyridines - administration & dosage</subject><ispartof>Alimentary pharmacology & therapeutics, 2004-09, Vol.20 (5), p.559-565</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright 2004 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4617-4bfc0e9c00ec99740209514a22dbd2cdb161cb003d28570b0bc4862fa0df0c9a3</citedby><cites>FETCH-LOGICAL-c4617-4bfc0e9c00ec99740209514a22dbd2cdb161cb003d28570b0bc4862fa0df0c9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2004.02147.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2004.02147.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16088061$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15339327$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujisawa, T.</creatorcontrib><creatorcontrib>Adachi, K.</creatorcontrib><creatorcontrib>Komazawa, Y.</creatorcontrib><creatorcontrib>Mihara, T.</creatorcontrib><creatorcontrib>Azumi, T.</creatorcontrib><creatorcontrib>Katsube, T.</creatorcontrib><creatorcontrib>Furuta, K.</creatorcontrib><creatorcontrib>Kazumori, H.</creatorcontrib><creatorcontrib>Kinoshita, Y.</creatorcontrib><title>Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background : The attenuated anti‐secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether Helicobacter pylori infection affects the occurrence of tolerance to H2RA. It is also not clarified whether the tolerance phenomenon occurs to a new H2RA, lafutidine.
Aim : To investigate the occurrence of the tolerance phenomenon in subjects with and without H. pylori infection during the continuous administration of lafutidine and famotidine.
Subjects and Methods : Subjects were 20 healthy male volunteers (seven H. pylori positive and 13 H. pylori negative cases). All subjects were examined by ambulatory intragastric pH monitoring five times without medication, on the first and 15th day of the administration of 20 mg b.d. famotidine and 10 mg b.d. lafutidine in a cross‐over fashion.
Results : The tolerance phenomenon was not observed in H. pylori‐positive subjects during the 15‐day‐long administration of both H2RAs. In contrast, the tolerance phenomenon was observed in H. pylori negative subjects, which has been previously reported.
Conclusions : This study demonstrated that H. pylori infection affects the tolerance phenomenon during continuous administration of H2RAs.</description><subject>Acetamides - administration & dosage</subject><subject>Adult</subject><subject>Ambulatory Care</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm</subject><subject>Cross-Over Studies</subject><subject>Cross-Sectional Studies</subject><subject>Digestive system</subject><subject>Drug Tolerance - physiology</subject><subject>Famotidine - administration & dosage</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Helicobacter Infections - physiopathology</subject><subject>Helicobacter pylori</subject><subject>Histamine H2 Antagonists - administration & dosage</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Piperidines - administration & dosage</subject><subject>Pyridines - administration & dosage</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMFu3CAQhlHUKtmkfYWKS3uzO4AX24ceoqjtRoqUHNIzwuNxl5UNLniT7NvXzq6aa5EQo_m_AfQxxgXkYl5fd7lQep1JUDqXAEUOUhRl_nLGVv-Cd2wFUteZrIS6YJcp7QBAlyDP2YVYK1UrWa7Y04Z6h6GxOFHk46EP0XHnO8LJBc_HSE_kp8SnLfGAuI-RPM5l99qZQk_RLo1xSz4M8_ZLtnVpsoPzxDeSR0IapxC59ZP9HfycpQ_sfWf7RB9P5xX79eP7480mu7v_eXtzfZdhoUWZFU2HQDUCENZ1WYCEei0KK2XbtBLbRmiBDYBqZbUuoYEGi0rLzkLbAdZWXbEvx3vHGP7sKU1mcAmp762nsE9G60qpUusZrI4gxpBSpM6M0Q02HowAszg3O7OoNYtaszg3r87Nyzz66fTGvhmofRs8SZ6BzyfAJrR9txhz6Y3TUFWgxcx9O3LPrqfDf3_AXD88LpX6C33Znxs</recordid><startdate>200409</startdate><enddate>200409</enddate><creator>Fujisawa, T.</creator><creator>Adachi, K.</creator><creator>Komazawa, Y.</creator><creator>Mihara, T.</creator><creator>Azumi, T.</creator><creator>Katsube, T.</creator><creator>Furuta, K.</creator><creator>Kazumori, H.</creator><creator>Kinoshita, Y.</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200409</creationdate><title>Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists</title><author>Fujisawa, T. ; Adachi, K. ; Komazawa, Y. ; Mihara, T. ; Azumi, T. ; Katsube, T. ; Furuta, K. ; Kazumori, H. ; Kinoshita, Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4617-4bfc0e9c00ec99740209514a22dbd2cdb161cb003d28570b0bc4862fa0df0c9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acetamides - administration & dosage</topic><topic>Adult</topic><topic>Ambulatory Care</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm</topic><topic>Cross-Over Studies</topic><topic>Cross-Sectional Studies</topic><topic>Digestive system</topic><topic>Drug Tolerance - physiology</topic><topic>Famotidine - administration & dosage</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Helicobacter Infections - physiopathology</topic><topic>Helicobacter pylori</topic><topic>Histamine H2 Antagonists - administration & dosage</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Piperidines - administration & dosage</topic><topic>Pyridines - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujisawa, T.</creatorcontrib><creatorcontrib>Adachi, K.</creatorcontrib><creatorcontrib>Komazawa, Y.</creatorcontrib><creatorcontrib>Mihara, T.</creatorcontrib><creatorcontrib>Azumi, T.</creatorcontrib><creatorcontrib>Katsube, T.</creatorcontrib><creatorcontrib>Furuta, K.</creatorcontrib><creatorcontrib>Kazumori, H.</creatorcontrib><creatorcontrib>Kinoshita, Y.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujisawa, T.</au><au>Adachi, K.</au><au>Komazawa, Y.</au><au>Mihara, T.</au><au>Azumi, T.</au><au>Katsube, T.</au><au>Furuta, K.</au><au>Kazumori, H.</au><au>Kinoshita, Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2004-09</date><risdate>2004</risdate><volume>20</volume><issue>5</issue><spage>559</spage><epage>565</epage><pages>559-565</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background : The attenuated anti‐secretory activity of H2 receptor antagonists (H2RA) during continuous administration is referred to as the tolerance phenomenon. However, it is not clarified whether Helicobacter pylori infection affects the occurrence of tolerance to H2RA. It is also not clarified whether the tolerance phenomenon occurs to a new H2RA, lafutidine.
Aim : To investigate the occurrence of the tolerance phenomenon in subjects with and without H. pylori infection during the continuous administration of lafutidine and famotidine.
Subjects and Methods : Subjects were 20 healthy male volunteers (seven H. pylori positive and 13 H. pylori negative cases). All subjects were examined by ambulatory intragastric pH monitoring five times without medication, on the first and 15th day of the administration of 20 mg b.d. famotidine and 10 mg b.d. lafutidine in a cross‐over fashion.
Results : The tolerance phenomenon was not observed in H. pylori‐positive subjects during the 15‐day‐long administration of both H2RAs. In contrast, the tolerance phenomenon was observed in H. pylori negative subjects, which has been previously reported.
Conclusions : This study demonstrated that H. pylori infection affects the tolerance phenomenon during continuous administration of H2RAs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15339327</pmid><doi>10.1111/j.1365-2036.2004.02147.x</doi><tpages>7</tpages></addata></record> |
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| source | Wiley Free Content; MEDLINE; IngentaConnect Free/Open Access Journals; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetamides - administration & dosage Adult Ambulatory Care Biological and medical sciences Circadian Rhythm Cross-Over Studies Cross-Sectional Studies Digestive system Drug Tolerance - physiology Famotidine - administration & dosage Gastroenterology. Liver. Pancreas. Abdomen Helicobacter Infections - physiopathology Helicobacter pylori Histamine H2 Antagonists - administration & dosage Humans Hydrogen-Ion Concentration Male Medical sciences Middle Aged Pharmacology. Drug treatments Piperidines - administration & dosage Pyridines - administration & dosage |
| title | Helicobacter pylori infection prevents the occurrence of the tolerance phenomenon of histamine H2 receptor antagonists |
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