High resolution in situ zymography reveals matrix metalloproteinase activity at glutamatergic synapses

Abstract Synaptic plasticity involves remodeling of extracellular matrix. This is mediated, in part, by enzymes of the matrix metalloproteinase (MMP) family, in particular by gelatinase MMP-9. Accordingly, there is a need of developing methods to visualize gelatinolytic activity at the level of indi...

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Veröffentlicht in:	Neuroscience 2009-01, Vol.158 (1), p.167-176
Hauptverfasser:	Gawlak, M, Górkiewicz, T, Gorlewicz, A, Konopacki, F.A, Kaczmarek, L, Wilczynski, G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay - methods Brain - enzymology Brain - ultrastructure Epilepsy - enzymology Epilepsy - physiopathology Extracellular Matrix - metabolism Fluorescent Antibody Technique - methods Glutamic Acid - metabolism Male Matrix Metalloproteinases - analysis Matrix Metalloproteinases - metabolism Microscopy, Fluorescence - methods Neurochemistry - methods Neurology Proteomics - methods Rats Rats, Wistar Rattus norvegicus Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism Synapses - enzymology Synapses - ultrastructure Tissue Embedding - methods Tissue Fixation - methods
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