Defining strategies to extend duration of gene expression from targeted compacted DNA vectors

Gene transfer complexes containing poly-L-lysine (poly-K) and DNA with ligands directed at the serpin enzyme complex receptor (sec-R) deliver reporter genes to receptor-bearing cells in vivo . Expression lasts for about 30 days, when complexes containing long-chain poly-K are used. Extending the dur...

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Veröffentlicht in:	Gene therapy 2004-09, Vol.11 (18), p.1378-1390
Hauptverfasser:	Ziady, A-G, Kim, J, Colla, J, Davis, P B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Antibodies Antibody Formation Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Cell Biology Cell receptors Cell structures and functions Coagulation factors Deoxyribonucleic acid DNA DNA - administration & dosage Expression vectors Factor IX - genetics Fundamental and applied biological sciences. Psychology Gene Expression Gene Therapy Gene transfer Genetic engineering Genetic Therapy - methods Health. Pharmaceutical industry Human Genetics Immune response Immunodeficiency Industrial applications and implications. Economical aspects Injections, Intravenous Lac Operon Ligands Lysine Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Miscellaneous Molecular and cellular biology Nanotechnology Poly-L-lysine Receptors, Cell Surface - metabolism Reporter gene research-article Serpins - genetics Spleen Time Factors Transfusions. Complications. Transfusion reactions. Cell and gene therapy
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