Antibiotic-induced lateral transfer of antibiotic resistance

Antibiotic-induced lateral transfer of antibiotic resistance

As do many temperate bacteriophages, integrating conjugative elements (ICEs) recruit the SOS DNA damage response to mobilize themselves from the bacterial chromosome and infect other cells. This transfers resistance to multiple antibiotics. Several commonly used antibiotics induce the SOS response,...

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Veröffentlicht in:Trends in microbiology (Regular ed.) 2004-09, Vol.12 (9), p.401-404
Hauptverfasser: Hastings, P.J., Rosenberg, Susan M., Slack, Andrew
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - genetics
DNA Damage
Drug Resistance - genetics
Gene Transfer, Horizontal
Genes, Bacterial
SOS Response (Genetics) - drug effects
SOS Response (Genetics) - genetics
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Zusammenfassung:As do many temperate bacteriophages, integrating conjugative elements (ICEs) recruit the SOS DNA damage response to mobilize themselves from the bacterial chromosome and infect other cells. This transfers resistance to multiple antibiotics. Several commonly used antibiotics induce the SOS response, potentially hastening genetic change and the evolution to resistance of pathogenic populations. The use of such antibiotics should be reconsidered.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2004.07.003