Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock
Circadian rhythms of physiology and behavior are generated by biological clocks that are synchronized to the cyclic environment by photic or nonphotic cues. The interactions and integration of various entrainment pathways to the clock are poorly understood. Here, we show that the Ras-like G protein...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 2004-09, Vol.43 (5), p.715-728 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Cheng, Hai-Ying M. Obrietan, Karl Cain, Sean W. Lee, Bo Young Agostino, Patricia V. Joza, Nicholas A. Harrington, Mary E. Ralph, Martin R. Penninger, Josef M. |
| description | Circadian rhythms of physiology and behavior are generated by biological clocks that are synchronized to the cyclic environment by photic or nonphotic cues. The interactions and integration of various entrainment pathways to the clock are poorly understood. Here, we show that the Ras-like G protein Dexras1 is a critical modulator of the responsiveness of the master clock to photic and nonphotic inputs. Genetic deletion of Dexras1 reduces photic entrainment by eliminating a pertussis-sensitive circadian response to NMDA. Mechanistically, Dexras1 couples NMDA and light input to G
i/o and ERK activation. In addition, the mutation greatly potentiates nonphotic responses to neuropeptide Y and unmasks a nonphotic response to arousal. Thus, Dexras1 modulates the responses of the master clock to photic and nonphotic stimuli in opposite directions. These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system. |
| doi_str_mv | 10.1016/j.neuron.2004.08.021 |
| format | Article |
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i/o and ERK activation. In addition, the mutation greatly potentiates nonphotic responses to neuropeptide Y and unmasks a nonphotic response to arousal. Thus, Dexras1 modulates the responses of the master clock to photic and nonphotic stimuli in opposite directions. These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/j.neuron.2004.08.021</identifier><identifier>PMID: 15339652</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Behavior ; Biological Clocks - genetics ; Biological Clocks - radiation effects ; Circadian rhythm ; Circadian Rhythm - genetics ; Circadian Rhythm - radiation effects ; Glutamic Acid - metabolism ; GTP-Binding Protein alpha Subunits, Gi-Go - metabolism ; GTP-Binding Proteins - genetics ; GTP-Binding Proteins - physiology ; Light ; Light Signal Transduction - drug effects ; Light Signal Transduction - genetics ; Medical research ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinases - metabolism ; Mutation - genetics ; Neuropeptide Y - metabolism ; Pertussis Toxin - pharmacology ; Photic Stimulation ; Proteins ; ras Proteins - genetics ; ras Proteins - physiology ; Receptors, N-Methyl-D-Aspartate - metabolism ; Retinal Ganglion Cells - cytology ; Retinal Ganglion Cells - metabolism ; Retinal Ganglion Cells - radiation effects ; Rodents ; Suprachiasmatic Nucleus - cytology ; Suprachiasmatic Nucleus - metabolism ; Suprachiasmatic Nucleus - radiation effects ; Synaptic Transmission - drug effects ; Synaptic Transmission - genetics ; Visual Pathways - cytology ; Visual Pathways - metabolism ; Visual Pathways - radiation effects</subject><ispartof>Neuron (Cambridge, Mass.), 2004-09, Vol.43 (5), p.715-728</ispartof><rights>2004 Cell Press</rights><rights>Copyright Elsevier Limited Sep 2, 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-422e0aa96ff3e3ad2fb69536be654b28c365f5620c9b78f42ea3728f6eb7b7e73</citedby><cites>FETCH-LOGICAL-c529t-422e0aa96ff3e3ad2fb69536be654b28c365f5620c9b78f42ea3728f6eb7b7e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuron.2004.08.021$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15339652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Hai-Ying M.</creatorcontrib><creatorcontrib>Obrietan, Karl</creatorcontrib><creatorcontrib>Cain, Sean W.</creatorcontrib><creatorcontrib>Lee, Bo Young</creatorcontrib><creatorcontrib>Agostino, Patricia V.</creatorcontrib><creatorcontrib>Joza, Nicholas A.</creatorcontrib><creatorcontrib>Harrington, Mary E.</creatorcontrib><creatorcontrib>Ralph, Martin R.</creatorcontrib><creatorcontrib>Penninger, Josef M.</creatorcontrib><title>Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Circadian rhythms of physiology and behavior are generated by biological clocks that are synchronized to the cyclic environment by photic or nonphotic cues. The interactions and integration of various entrainment pathways to the clock are poorly understood. Here, we show that the Ras-like G protein Dexras1 is a critical modulator of the responsiveness of the master clock to photic and nonphotic inputs. Genetic deletion of Dexras1 reduces photic entrainment by eliminating a pertussis-sensitive circadian response to NMDA. Mechanistically, Dexras1 couples NMDA and light input to G
i/o and ERK activation. In addition, the mutation greatly potentiates nonphotic responses to neuropeptide Y and unmasks a nonphotic response to arousal. Thus, Dexras1 modulates the responses of the master clock to photic and nonphotic stimuli in opposite directions. These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system.</description><subject>Animals</subject><subject>Behavior</subject><subject>Biological Clocks - genetics</subject><subject>Biological Clocks - radiation effects</subject><subject>Circadian rhythm</subject><subject>Circadian Rhythm - genetics</subject><subject>Circadian Rhythm - radiation effects</subject><subject>Glutamic Acid - metabolism</subject><subject>GTP-Binding Protein alpha Subunits, Gi-Go - metabolism</subject><subject>GTP-Binding Proteins - genetics</subject><subject>GTP-Binding Proteins - physiology</subject><subject>Light</subject><subject>Light Signal Transduction - drug effects</subject><subject>Light Signal Transduction - genetics</subject><subject>Medical research</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mitogen-Activated Protein Kinases - metabolism</subject><subject>Mutation - genetics</subject><subject>Neuropeptide Y - metabolism</subject><subject>Pertussis Toxin - pharmacology</subject><subject>Photic Stimulation</subject><subject>Proteins</subject><subject>ras Proteins - genetics</subject><subject>ras Proteins - physiology</subject><subject>Receptors, N-Methyl-D-Aspartate - metabolism</subject><subject>Retinal Ganglion Cells - cytology</subject><subject>Retinal Ganglion Cells - metabolism</subject><subject>Retinal Ganglion Cells - radiation effects</subject><subject>Rodents</subject><subject>Suprachiasmatic Nucleus - cytology</subject><subject>Suprachiasmatic Nucleus - metabolism</subject><subject>Suprachiasmatic Nucleus - radiation effects</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - genetics</subject><subject>Visual Pathways - cytology</subject><subject>Visual Pathways - metabolism</subject><subject>Visual Pathways - radiation effects</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtr3DAQgEVJ6G62_QelGAK92dHDkq1LIWyaB4QkpOlZyPKI1XZXciQ7JP8-Nl4o9NCeBma-GY3mQ-gLwQXBRJxtCw9DDL6gGJcFrgtMyQe0JFhWeUmkPEJLXEuRC1qxBTpJaYsxKbkkH9GCcMak4HSJni7gNepEsofQg--d7iFlD5vQO5Np32Y_h66LkNKYvQu-mwuPkLrgp1ywWb-BbO2i0a3TPlvvgvn9CR1bvUvw-RBX6Nflj6f1dX57f3WzPr_NDaeyz0tKAWsthbUMmG6pbYTkTDQgeNnQ2jDBLRcUG9lUtS0paFbR2gpoqqaCiq3Qt3luF8PzAKlXe5cM7HbaQxiSEqKmkpfivyCp8XQPOYKnf4HbMEQ_fkIRjsd9yLThCpUzZWJIKYJVXXR7Hd8UwWqSo7ZqlqMmOQrXapQztn09DB-aPbR_mg42RuD7DMB4tBcHUSXjwBtoXQTTqza4f7_wDjfEobY</recordid><startdate>20040902</startdate><enddate>20040902</enddate><creator>Cheng, Hai-Ying M.</creator><creator>Obrietan, Karl</creator><creator>Cain, Sean W.</creator><creator>Lee, Bo Young</creator><creator>Agostino, Patricia V.</creator><creator>Joza, Nicholas A.</creator><creator>Harrington, Mary E.</creator><creator>Ralph, Martin R.</creator><creator>Penninger, Josef M.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20040902</creationdate><title>Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock</title><author>Cheng, Hai-Ying M. ; Obrietan, Karl ; Cain, Sean W. ; Lee, Bo Young ; Agostino, Patricia V. ; Joza, Nicholas A. ; Harrington, Mary E. ; Ralph, Martin R. ; Penninger, Josef M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-422e0aa96ff3e3ad2fb69536be654b28c365f5620c9b78f42ea3728f6eb7b7e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Biological Clocks - genetics</topic><topic>Biological Clocks - radiation effects</topic><topic>Circadian rhythm</topic><topic>Circadian Rhythm - genetics</topic><topic>Circadian Rhythm - radiation effects</topic><topic>Glutamic Acid - metabolism</topic><topic>GTP-Binding Protein alpha Subunits, Gi-Go - metabolism</topic><topic>GTP-Binding Proteins - genetics</topic><topic>GTP-Binding Proteins - physiology</topic><topic>Light</topic><topic>Light Signal Transduction - drug effects</topic><topic>Light Signal Transduction - genetics</topic><topic>Medical research</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Mitogen-Activated Protein Kinases - metabolism</topic><topic>Mutation - genetics</topic><topic>Neuropeptide Y - metabolism</topic><topic>Pertussis Toxin - pharmacology</topic><topic>Photic Stimulation</topic><topic>Proteins</topic><topic>ras Proteins - genetics</topic><topic>ras Proteins - physiology</topic><topic>Receptors, N-Methyl-D-Aspartate - metabolism</topic><topic>Retinal Ganglion Cells - cytology</topic><topic>Retinal Ganglion Cells - metabolism</topic><topic>Retinal Ganglion Cells - radiation effects</topic><topic>Rodents</topic><topic>Suprachiasmatic Nucleus - cytology</topic><topic>Suprachiasmatic Nucleus - metabolism</topic><topic>Suprachiasmatic Nucleus - radiation effects</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - genetics</topic><topic>Visual Pathways - cytology</topic><topic>Visual Pathways - metabolism</topic><topic>Visual Pathways - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Hai-Ying M.</creatorcontrib><creatorcontrib>Obrietan, Karl</creatorcontrib><creatorcontrib>Cain, Sean W.</creatorcontrib><creatorcontrib>Lee, Bo Young</creatorcontrib><creatorcontrib>Agostino, Patricia V.</creatorcontrib><creatorcontrib>Joza, Nicholas A.</creatorcontrib><creatorcontrib>Harrington, Mary E.</creatorcontrib><creatorcontrib>Ralph, Martin R.</creatorcontrib><creatorcontrib>Penninger, Josef M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Hai-Ying M.</au><au>Obrietan, Karl</au><au>Cain, Sean W.</au><au>Lee, Bo Young</au><au>Agostino, Patricia V.</au><au>Joza, Nicholas A.</au><au>Harrington, Mary E.</au><au>Ralph, Martin R.</au><au>Penninger, Josef M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>2004-09-02</date><risdate>2004</risdate><volume>43</volume><issue>5</issue><spage>715</spage><epage>728</epage><pages>715-728</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>Circadian rhythms of physiology and behavior are generated by biological clocks that are synchronized to the cyclic environment by photic or nonphotic cues. The interactions and integration of various entrainment pathways to the clock are poorly understood. Here, we show that the Ras-like G protein Dexras1 is a critical modulator of the responsiveness of the master clock to photic and nonphotic inputs. Genetic deletion of Dexras1 reduces photic entrainment by eliminating a pertussis-sensitive circadian response to NMDA. Mechanistically, Dexras1 couples NMDA and light input to G
i/o and ERK activation. In addition, the mutation greatly potentiates nonphotic responses to neuropeptide Y and unmasks a nonphotic response to arousal. Thus, Dexras1 modulates the responses of the master clock to photic and nonphotic stimuli in opposite directions. These results identify a signaling molecule that serves as a differential modulator of the gated photic and nonphotic input pathways to the circadian timekeeping system.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15339652</pmid><doi>10.1016/j.neuron.2004.08.021</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Behavior Biological Clocks - genetics Biological Clocks - radiation effects Circadian rhythm Circadian Rhythm - genetics Circadian Rhythm - radiation effects Glutamic Acid - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - metabolism GTP-Binding Proteins - genetics GTP-Binding Proteins - physiology Light Light Signal Transduction - drug effects Light Signal Transduction - genetics Medical research Mice Mice, Knockout Mitogen-Activated Protein Kinases - metabolism Mutation - genetics Neuropeptide Y - metabolism Pertussis Toxin - pharmacology Photic Stimulation Proteins ras Proteins - genetics ras Proteins - physiology Receptors, N-Methyl-D-Aspartate - metabolism Retinal Ganglion Cells - cytology Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - radiation effects Rodents Suprachiasmatic Nucleus - cytology Suprachiasmatic Nucleus - metabolism Suprachiasmatic Nucleus - radiation effects Synaptic Transmission - drug effects Synaptic Transmission - genetics Visual Pathways - cytology Visual Pathways - metabolism Visual Pathways - radiation effects |
| title | Dexras1 Potentiates Photic and Suppresses Nonphotic Responses of the Circadian Clock |
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