ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma

A micro-array analysis using biopsies from patients with EBV-positive undifferentiated nasopharyngeal carcinoma (NPC) and from cancer-free controls revealed down-regulation of tumour suppressor genes (TSG) not previously associated with this disease; one such gene was the ataxia telangiectasia mutat...

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Veröffentlicht in:	The Journal of pathology 2009-02, Vol.217 (3), p.345-352
Hauptverfasser:	Bose, Shikha, Yap, Lee-Fah, Fung, Matthew, Starzcynski, Jane, Saleh, Amyza, Morgan, Susan, Dawson, Christopher, Chukwuma, Marilyn B, Maina, Esther, Buettner, Maike, Wei, Wenbin, Arrand, John, Lim, Paul VH, Young, Lawrence S, Teo, Soo Hwang, Stankovic, Tatjana, Woodman, Ciaran BJ, Murray, Paul G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - virology Ataxia Telangiectasia Mutated Proteins ATM Biological and medical sciences Case-Control Studies Cell Cycle Proteins - analysis Cell Cycle Proteins - genetics Cell Line, Tumor DNA-Binding Proteins - analysis DNA-Binding Proteins - genetics Down-Regulation Epstein-Barr virus Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Gene Expression Regulation, Viral Herpesvirus 4, Human Humans Immunohistochemistry Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Medical sciences nasopharyngeal carcinoma Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - virology Oligonucleotide Array Sequence Analysis Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein-Serine-Threonine Kinases - analysis Protein-Serine-Threonine Kinases - genetics Reverse Transcriptase Polymerase Chain Reaction Tumor Suppressor Proteins - analysis Tumor Suppressor Proteins - genetics Tumor Virus Infections - complications Tumor Virus Infections - genetics Viral diseases
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