Effects of CFTR, interleukin-10, and Pseudomonas aeruginosa on gene expression profiles in a CF bronchial epithelial cell Line

Mutations in CFTR lead to a complex phenotype that includes increased susceptibility to Pseudomonas infections, a functional deficiency of IL-10, and an exaggerated proinflammatory cytokine response. We examined the effects of CFTR gene correction on the gene expression profile of a CF bronchial epi...

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Veröffentlicht in:	Molecular therapy 2004-09, Vol.10 (3), p.562-573
Hauptverfasser:	Virella-Lowell, Isabel, Herlihy, John-David, Liu, Barry, Lopez, Cecilia, Cruz, Pedro, Muller, Chris, Baker, Henry V, Flotte, Terence R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bronchi - cytology Bronchi - metabolism Cell Line Cystic fibrosis Cystic Fibrosis - genetics Cystic Fibrosis Transmembrane Conductance Regulator - biosynthesis Cystic Fibrosis Transmembrane Conductance Regulator - genetics Cytokines Datasets Enzymes Epithelial Cells - metabolism Gene expression Gene Expression Profiling Gene therapy Genomics Humans Interleukin-10 - biosynthesis Interleukin-10 - genetics Lung diseases Mutation Neutrophils Pediatrics Proteins Pseudomonas aeruginosa Respiratory Mucosa - cytology Respiratory Mucosa - metabolism Transfection
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