The Preconditioning Effect of Sevoflurane on the Oxygen Glucose-Deprived Hippocampal Slice: The Role of Tyrosine Kinases and Duration of Ischemia

The neuroprotective efficacy of anesthetics observed in experimental models remains unproven in the clinical setting. The nonreceptor tyrosine kinase focal adhesion kinase (FAK) has been suggested to be involved in the neuroprotective effect of anesthetics observed experimentally. In the present wor...

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Veröffentlicht in:	Anesthesia and analgesia 2009-02, Vol.108 (2), p.601-608
Hauptverfasser:	Sigaut, Stéphanie, Jannier, Virginie, Rouelle, Danielle, Gressens, Pierre, Mantz, Jean, Dahmani, Souhayl
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Anesthetics, Inhalation - pharmacology Animals Biological and medical sciences Blood Gas Analysis Brain Ischemia - enzymology Brain Ischemia - physiopathology Caspase 3 - metabolism Cell Death - drug effects Cerebrovascular Circulation - drug effects Cerebrovascular Circulation - physiology Focal Adhesion Protein-Tyrosine Kinases - physiology Glucose - deficiency Hippocampus - blood supply Hippocampus - enzymology Hippocampus - physiopathology Hydrogen-Ion Concentration Hypoxia, Brain - enzymology Hypoxia, Brain - physiopathology Male Medical sciences Methyl Ethers - pharmacology Neuroprotective Agents Phosphorylation Rats Rats, Sprague-Dawley Signal Transduction - physiology
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