SPCA1 pumps and Hailey–Hailey disease
Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca 2+ stores. The Golgi apparatus has Ca 2+-release channels and a Ca 2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca 2+-ATPases (SERCA) and secretory-pathway Ca 2+-ATPases (SPCA). SPCA1 has...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2004-10, Vol.322 (4), p.1204-1213 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Missiaen, Ludwig Raeymaekers, Luc Dode, Leonard Vanoevelen, Jo Van Baelen, Kurt Parys, Jan B. Callewaert, Geert De Smedt, Humbert Segaert, Siegfried Wuytack, Frank |
| description | Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca
2+ stores. The Golgi apparatus has Ca
2+-release channels and a Ca
2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca
2+-ATPases (SERCA) and secretory-pathway Ca
2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca
2+ and Mn
2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca
2+ and Mn
2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (
ATP2C1) gene causes Hailey–Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated. |
| doi_str_mv | 10.1016/j.bbrc.2004.07.128 |
| format | Article |
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2+ stores. The Golgi apparatus has Ca
2+-release channels and a Ca
2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca
2+-ATPases (SERCA) and secretory-pathway Ca
2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca
2+ and Mn
2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca
2+ and Mn
2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (
ATP2C1) gene causes Hailey–Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2004.07.128</identifier><identifier>PMID: 15336968</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Animals ; Calcium - metabolism ; Calcium pump ; Calcium store ; Calcium-Transporting ATPases - genetics ; Calcium-Transporting ATPases - physiology ; Dermatology ; Female ; Golgi apparatus ; Golgi Apparatus - enzymology ; Hailey–Hailey disease ; Humans ; Intracellular calcium ; Manganese - metabolism ; Pemphigus, Benign Familial - enzymology ; Pemphigus, Benign Familial - genetics ; Pemphigus, Benign Familial - pathology ; Secretory pathway</subject><ispartof>Biochemical and biophysical research communications, 2004-10, Vol.322 (4), p.1204-1213</ispartof><rights>2004 Elsevier Inc.</rights><rights>Copyright 2004 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-de69448ebd4ab5b641d2b863d4e9875f89bf22f92037a48d9b535f61bcb0547c3</citedby><cites>FETCH-LOGICAL-c383t-de69448ebd4ab5b641d2b863d4e9875f89bf22f92037a48d9b535f61bcb0547c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbrc.2004.07.128$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15336968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Missiaen, Ludwig</creatorcontrib><creatorcontrib>Raeymaekers, Luc</creatorcontrib><creatorcontrib>Dode, Leonard</creatorcontrib><creatorcontrib>Vanoevelen, Jo</creatorcontrib><creatorcontrib>Van Baelen, Kurt</creatorcontrib><creatorcontrib>Parys, Jan B.</creatorcontrib><creatorcontrib>Callewaert, Geert</creatorcontrib><creatorcontrib>De Smedt, Humbert</creatorcontrib><creatorcontrib>Segaert, Siegfried</creatorcontrib><creatorcontrib>Wuytack, Frank</creatorcontrib><title>SPCA1 pumps and Hailey–Hailey disease</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca
2+ stores. The Golgi apparatus has Ca
2+-release channels and a Ca
2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca
2+-ATPases (SERCA) and secretory-pathway Ca
2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca
2+ and Mn
2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca
2+ and Mn
2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (
ATP2C1) gene causes Hailey–Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated.</description><subject>Adult</subject><subject>Animals</subject><subject>Calcium - metabolism</subject><subject>Calcium pump</subject><subject>Calcium store</subject><subject>Calcium-Transporting ATPases - genetics</subject><subject>Calcium-Transporting ATPases - physiology</subject><subject>Dermatology</subject><subject>Female</subject><subject>Golgi apparatus</subject><subject>Golgi Apparatus - enzymology</subject><subject>Hailey–Hailey disease</subject><subject>Humans</subject><subject>Intracellular calcium</subject><subject>Manganese - metabolism</subject><subject>Pemphigus, Benign Familial - enzymology</subject><subject>Pemphigus, Benign Familial - genetics</subject><subject>Pemphigus, Benign Familial - pathology</subject><subject>Secretory pathway</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1Kw0AURgdRbK2-gAvpSleJdyaT-QE3pagVCgoquBsyMzeQkjQx0wjd-Q6-oU9iSgrudHXv4nxncQg5pxBToOJ6FVvbupgB8BhkTJk6IGMKGiJGgR-SMQCIiGn6NiInIawAKOVCH5MRTZNEaKHG5Or5aT6j06armjDN1n66yIoSt9-fX8Mz9UXALOApOcqzMuDZ_k7I693ty3wRLR_vH-azZeQSlWwij0JzrtB6ntnUCk49s0oknqNWMs2VtjljuWaQyIwrr22apLmg1llIuXTJhFwO3qat3zsMG1MVwWFZZmusu2CEUEwICf-CVEqQmqU9yAbQtXUILeamaYsqa7eGgtl1NCuz62h2HQ1I03fsRxd7e2cr9L-TfbgeuBkA7GN8FNia4ApcO_RFi25jfF385f8BQfiCWQ</recordid><startdate>20041001</startdate><enddate>20041001</enddate><creator>Missiaen, Ludwig</creator><creator>Raeymaekers, Luc</creator><creator>Dode, Leonard</creator><creator>Vanoevelen, Jo</creator><creator>Van Baelen, Kurt</creator><creator>Parys, Jan B.</creator><creator>Callewaert, Geert</creator><creator>De Smedt, Humbert</creator><creator>Segaert, Siegfried</creator><creator>Wuytack, Frank</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20041001</creationdate><title>SPCA1 pumps and Hailey–Hailey disease</title><author>Missiaen, Ludwig ; Raeymaekers, Luc ; Dode, Leonard ; Vanoevelen, Jo ; Van Baelen, Kurt ; Parys, Jan B. ; Callewaert, Geert ; De Smedt, Humbert ; Segaert, Siegfried ; Wuytack, Frank</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-de69448ebd4ab5b641d2b863d4e9875f89bf22f92037a48d9b535f61bcb0547c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Animals</topic><topic>Calcium - metabolism</topic><topic>Calcium pump</topic><topic>Calcium store</topic><topic>Calcium-Transporting ATPases - genetics</topic><topic>Calcium-Transporting ATPases - physiology</topic><topic>Dermatology</topic><topic>Female</topic><topic>Golgi apparatus</topic><topic>Golgi Apparatus - enzymology</topic><topic>Hailey–Hailey disease</topic><topic>Humans</topic><topic>Intracellular calcium</topic><topic>Manganese - metabolism</topic><topic>Pemphigus, Benign Familial - enzymology</topic><topic>Pemphigus, Benign Familial - genetics</topic><topic>Pemphigus, Benign Familial - pathology</topic><topic>Secretory pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Missiaen, Ludwig</creatorcontrib><creatorcontrib>Raeymaekers, Luc</creatorcontrib><creatorcontrib>Dode, Leonard</creatorcontrib><creatorcontrib>Vanoevelen, Jo</creatorcontrib><creatorcontrib>Van Baelen, Kurt</creatorcontrib><creatorcontrib>Parys, Jan B.</creatorcontrib><creatorcontrib>Callewaert, Geert</creatorcontrib><creatorcontrib>De Smedt, Humbert</creatorcontrib><creatorcontrib>Segaert, Siegfried</creatorcontrib><creatorcontrib>Wuytack, Frank</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Missiaen, Ludwig</au><au>Raeymaekers, Luc</au><au>Dode, Leonard</au><au>Vanoevelen, Jo</au><au>Van Baelen, Kurt</au><au>Parys, Jan B.</au><au>Callewaert, Geert</au><au>De Smedt, Humbert</au><au>Segaert, Siegfried</au><au>Wuytack, Frank</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SPCA1 pumps and Hailey–Hailey disease</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2004-10-01</date><risdate>2004</risdate><volume>322</volume><issue>4</issue><spage>1204</spage><epage>1213</epage><pages>1204-1213</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca
2+ stores. The Golgi apparatus has Ca
2+-release channels and a Ca
2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca
2+-ATPases (SERCA) and secretory-pathway Ca
2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca
2+ and Mn
2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca
2+ and Mn
2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (
ATP2C1) gene causes Hailey–Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>15336968</pmid><doi>10.1016/j.bbrc.2004.07.128</doi><tpages>10</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2004-10, Vol.322 (4), p.1204-1213 |
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| subjects | Adult Animals Calcium - metabolism Calcium pump Calcium store Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - physiology Dermatology Female Golgi apparatus Golgi Apparatus - enzymology Hailey–Hailey disease Humans Intracellular calcium Manganese - metabolism Pemphigus, Benign Familial - enzymology Pemphigus, Benign Familial - genetics Pemphigus, Benign Familial - pathology Secretory pathway |
| title | SPCA1 pumps and Hailey–Hailey disease |
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