Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold ‘em, knowing when to fold ‘em
Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, m...
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| Veröffentlicht in: | Trends in microbiology (Regular ed.) 2009-01, Vol.17 (1), p.13-21 |
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| container_title | Trends in microbiology (Regular ed.) |
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| creator | Hutchings, Matthew I Palmer, Tracy Harrington, Dean J Sutcliffe, Iain C |
| description | Gram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral membrane proteins. Recent advances in molecular biology and the availability of whole genome sequence data have overturned many long-held assumptions about the export and processing of these proteins, most notably the recent discovery that not all lipoproteins are exported as unfolded substrates through the general secretion pathway. Here, we review recent discoveries concerning the export and processing of these proteins, their role in virulence in Gram-positive bacteria and their potential as vaccine candidates or targets for new antimicrobials. |
| doi_str_mv | 10.1016/j.tim.2008.10.001 |
| format | Article |
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| identifier | ISSN: 0966-842X |
| ispartof | Trends in microbiology (Regular ed.), 2009-01, Vol.17 (1), p.13-21 |
| issn | 0966-842X 1878-4380 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Gene Expression Regulation, Bacterial Gram-Positive Bacteria - metabolism Gram-Positive Bacteria - pathogenicity Gram-Positive Bacterial Infections - microbiology Humans Internal Medicine Lipoproteins - biosynthesis Lipoproteins - chemistry Lipoproteins - genetics Lipoproteins - metabolism Mice Protein Folding Protein Transport Virulence |
| title | Lipoprotein biogenesis in Gram-positive bacteria: knowing when to hold ‘em, knowing when to fold ‘em |
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