Designing ageing conditions in tumour microenvironment—A new possible modality for cancer treatment

While tumour incidence is known to augment with age, paradoxically tumour growth and metastasis were often found to proceed at a slower rate at late ages. This age-related biological behaviour of tumours actually imposes a differential therapeutic approach to the old cancer patient. Several mechanis...

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Veröffentlicht in:	Mechanisms of ageing and development 2009-01, Vol.130 (1-2), p.76-85
Hauptverfasser:	Leibovici, Judith, Itzhaki, Orit, Kaptzan, Tatiana, Skutelsky, Ehud, Sinai, Judith, Michowitz, Moshe, Asfur, Raida, Siegal, Annette, Huszar, Monica, Schiby, Ginnette
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Age-adjusted therapy Ageing Aging - physiology Animals Antineoplastic Agents - pharmacology Cancer Disease Models, Animal Disease Progression Lymphoma - drug therapy Lymphoma - mortality Lymphoma - physiopathology Melanoma - drug therapy Melanoma - mortality Melanoma - physiopathology Mice Mice, Inbred AKR Mice, Inbred C57BL Severity of Illness Index Skin Neoplasms - drug therapy Skin Neoplasms - mortality Skin Neoplasms - physiopathology Survival Rate
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