Genetic manipulation of cardiac Na+/Ca2+ exchange expression

The Na+/Ca2+ exchanger (NCX) is the primary Ca2+ extrusion mechanism in cardiomyocytes. To further investigate the role of NCX in excitation-contraction coupling and Ca2+ homeostasis, we created murine models with altered expression levels of NCX. Homozygous overexpression of NCX resulted in mild ca...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-10, Vol.322 (4), p.1336-1340
Hauptverfasser:	Pott, Christian, Goldhaber, Joshua I, Philipson, Kenneth D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - metabolism Mice Mice, Knockout Myocardial Contraction Myocardium - metabolism Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism Sodium-Calcium Exchanger - physiology
Online-Zugang:	Volltext
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