A monoclonal antibody directed against human von Willebrand factor induces type 2B‐like alterations

We have previously described a monoclonal antibody (mAb), 1C1E7, against von Willebrand factor (VWF), that increases ristocetin‐induced platelet aggregation (RIPA) and induces a preferential binding of the high‐molecular‐weight multimers of VWF to platelet GPIb. Further investigations using a rotati...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2004-09, Vol.2 (9), p.1622-1628
Hauptverfasser:	Ulrichts, H., Harsfalvi, J., Bene, L., Matko, J., Vermylen, J., Ajzenberg, N., Baruch, D., Deckmyn, H., Tornai, I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology A‐domain Epitopes - chemistry Flow Cytometry Humans In Vitro Techniques Platelet Adhesiveness Platelet Aggregation - drug effects Protein Subunits Ristocetin - pharmacology shear stress von Willebrand Diseases - blood von Willebrand Diseases - immunology von Willebrand Factor - antagonists & inhibitors von Willebrand Factor - chemistry von Willebrand Factor - immunology von Willebrand's disease
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