Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2004-08, Vol.67 (8), p.1216-1238 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Newman, David J Cragg, Gordon M |
| description | The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases. |
| doi_str_mv | 10.1021/np040031y |
| format | Article |
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Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. 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Nat. Prod</addtitle><description>The marine environment has proven to be a very rich source of extremely potent compounds that have demonstrated significant activities in antitumor, antiinflammatory, analgesia, immunomodulation, allergy, and anti-viral assays. Although the case can and has been made that the nucleosides such as Ara-A and Ara-C are derived from knowledge gained from investigations of bioactive marine nucleosides, no drug directly from marine sources (whether isolated or by total synthesis) has yet made it to the commercial sector in any disease. However, as shown in this review, there are now significant numbers of very interesting molecules that have come from marine sources, or have been synthesized as a result of knowledge gained from a prototypical compound, that are either in or approaching Phase II/III clinical trials in cancer, analgesia, allergy, and cognitive diseases. A substantial number of other potential agents are following in their wake in preclinical trials in these and in other diseases.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Biological Products</subject><subject>Bones, joints and connective tissue. Antiinflammatory agents</subject><subject>Brackish</subject><subject>Clinical Trials as Topic</subject><subject>Drug Evaluation, Preclinical</subject><subject>General aspects</subject><subject>General pharmacology</subject><subject>Immunomodulators</subject><subject>Marine</subject><subject>Marine Biology</subject><subject>Medical sciences</subject><subject>Molecular Structure</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. 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Antiinflammatory agents</topic><topic>Brackish</topic><topic>Clinical Trials as Topic</topic><topic>Drug Evaluation, Preclinical</topic><topic>General aspects</topic><topic>General pharmacology</topic><topic>Immunomodulators</topic><topic>Marine</topic><topic>Marine Biology</topic><topic>Medical sciences</topic><topic>Molecular Structure</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newman, David J</creatorcontrib><creatorcontrib>Cragg, Gordon M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newman, David J</au><au>Cragg, Gordon M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. 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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2004-08, Vol.67 (8), p.1216-1238 |
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| language | eng |
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| source | ACS Publications; MEDLINE |
| subjects | Animals Antineoplastic agents Biological and medical sciences Biological Products Bones, joints and connective tissue. Antiinflammatory agents Brackish Clinical Trials as Topic Drug Evaluation, Preclinical General aspects General pharmacology Immunomodulators Marine Marine Biology Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments |
| title | Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials |
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