Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa

Bacterial resistance to antibiotic therapy remains a worldwide problem. In Pseudomonas aeruginosa, rates of efflux confer inherent resistance to many antimicrobial agents, including fluoroquinolones, due to a high level of expression and a relatively high turnover number of the efflux pumps in gram-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Analytical biochemistry 2009-02, Vol.385 (2), p.321-325
Hauptverfasser:	Cai, Hongliang, Rose, Kelly, Liang, Lan-Hsin, Dunham, Steve, Stover, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial accumulation Bacterial efflux Bacterial penetration Biological Transport Chromatography, Liquid Ciprofloxacin Ciprofloxacin - analysis Ciprofloxacin - metabolism Fluorescence LC/MS Pharmaceutical Preparations - analysis Pharmaceutical Preparations - metabolism Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Pyridinium Compounds Tandem Mass Spectrometry - methods
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!