Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma
To investigate the influence of the glutathione S-transferase (GST) M1, T1, and P1 genotypes on the laryngeal squamous cell carcinoma risk. The study group consisted of 42 white patients with laryngeal squamous cell carcinoma (39 of them were male, mean age: 53, range: 37–67 and 3 of them were femal...
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| Veröffentlicht in: | American journal of otolaryngology 2004-09, Vol.25 (5), p.318-322 |
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| creator | Ünal, Murat Tamer, Lülüfer Aras Ateş, Nurcan Akbaş, Yücel Pata, Yavuz Selim Vayisoğlu, Yusuf Ercan, Bahadır Görür, Kemal Atik, Uğur |
| description | To investigate the influence of the glutathione S-transferase (GST) M1, T1, and P1 genotypes on the laryngeal squamous cell carcinoma risk.
The study group consisted of 42 white patients with laryngeal squamous cell carcinoma (39 of them were male, mean age: 53, range: 37–67 and 3 of them were female, mean age: 47, range: 32–55) and 89 control subjects (nonsmokers = 47, smokers = 42) (58 male and 31 female, mean age: 51, range: 30–72). DNA samples were isolated from blood samples using high pure polymerase chain reaction (PCR) Template Preparation Kit. The detection of GST T1, GST M1, and P1 polymorphisms were detected by using real-time PCR.
Gene polymorphisms at GST M1 and P1 were not significantly different in patient and control groups. However, GST T1 null type significantly increased in laryngeal cancer patients when compared with the nonsmoking controls (
P = .04).
There was a significant association between GST T1 null genotype and laryngeal squamous cell carcinoma. However the potential role of GSTs as markers of susceptibility to laryngeal carcinoma needs further studies in a larger number of patients. |
| doi_str_mv | 10.1016/j.amjoto.2004.04.003 |
| format | Article |
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The study group consisted of 42 white patients with laryngeal squamous cell carcinoma (39 of them were male, mean age: 53, range: 37–67 and 3 of them were female, mean age: 47, range: 32–55) and 89 control subjects (nonsmokers = 47, smokers = 42) (58 male and 31 female, mean age: 51, range: 30–72). DNA samples were isolated from blood samples using high pure polymerase chain reaction (PCR) Template Preparation Kit. The detection of GST T1, GST M1, and P1 polymorphisms were detected by using real-time PCR.
Gene polymorphisms at GST M1 and P1 were not significantly different in patient and control groups. However, GST T1 null type significantly increased in laryngeal cancer patients when compared with the nonsmoking controls (
P = .04).
There was a significant association between GST T1 null genotype and laryngeal squamous cell carcinoma. However the potential role of GSTs as markers of susceptibility to laryngeal carcinoma needs further studies in a larger number of patients.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2004.04.003</identifier><identifier>PMID: 15334395</identifier><identifier>CODEN: AJOTDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Carcinoma, Squamous Cell - enzymology ; Carcinoma, Squamous Cell - genetics ; Case-Control Studies ; DNA, Neoplasm - chemistry ; DNA, Neoplasm - isolation & purification ; Female ; Genotype ; Glutathione Transferase - genetics ; Humans ; Laryngeal Neoplasms - enzymology ; Laryngeal Neoplasms - genetics ; Male ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Polymerase Chain Reaction ; Polymorphism, Genetic - genetics ; Risk Factors ; Smoking - adverse effects ; Smoking - genetics ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>American journal of otolaryngology, 2004-09, Vol.25 (5), p.318-322</ispartof><rights>2004 Elsevier Inc.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-3da9d91abea33eff9f8bfff9603adf3ae352dab27c07c25aacad5430c7eb4d9f3</citedby><cites>FETCH-LOGICAL-c416t-3da9d91abea33eff9f8bfff9603adf3ae352dab27c07c25aacad5430c7eb4d9f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.amjoto.2004.04.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16112548$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15334395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ünal, Murat</creatorcontrib><creatorcontrib>Tamer, Lülüfer</creatorcontrib><creatorcontrib>Aras Ateş, Nurcan</creatorcontrib><creatorcontrib>Akbaş, Yücel</creatorcontrib><creatorcontrib>Pata, Yavuz Selim</creatorcontrib><creatorcontrib>Vayisoğlu, Yusuf</creatorcontrib><creatorcontrib>Ercan, Bahadır</creatorcontrib><creatorcontrib>Görür, Kemal</creatorcontrib><creatorcontrib>Atik, Uğur</creatorcontrib><title>Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>To investigate the influence of the glutathione S-transferase (GST) M1, T1, and P1 genotypes on the laryngeal squamous cell carcinoma risk.
The study group consisted of 42 white patients with laryngeal squamous cell carcinoma (39 of them were male, mean age: 53, range: 37–67 and 3 of them were female, mean age: 47, range: 32–55) and 89 control subjects (nonsmokers = 47, smokers = 42) (58 male and 31 female, mean age: 51, range: 30–72). DNA samples were isolated from blood samples using high pure polymerase chain reaction (PCR) Template Preparation Kit. The detection of GST T1, GST M1, and P1 polymorphisms were detected by using real-time PCR.
Gene polymorphisms at GST M1 and P1 were not significantly different in patient and control groups. However, GST T1 null type significantly increased in laryngeal cancer patients when compared with the nonsmoking controls (
P = .04).
There was a significant association between GST T1 null genotype and laryngeal squamous cell carcinoma. However the potential role of GSTs as markers of susceptibility to laryngeal carcinoma needs further studies in a larger number of patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - enzymology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Case-Control Studies</subject><subject>DNA, Neoplasm - chemistry</subject><subject>DNA, Neoplasm - isolation & purification</subject><subject>Female</subject><subject>Genotype</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - enzymology</subject><subject>Laryngeal Neoplasms - genetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFq3DAQhkVoSLZp3iAUQWlP8VaybK19KZTQJoGEFJpCb2IsjRIZW9pIdiFvH5ldCPQQGDE6fDP88xFyxtmaMy6_9msY-zCFdclYtV6KiQOy4rUoi4Y3f9-RFeOtLNiGtcfkfUo9y0Ql6iNynKH8a-sVUZfDPMH06IJH-ruYIvhkMUJCesvP6X1-4A39xekDZmIbhucxxO2jSyN1ng4Qn_0DwkDT0wxjmBPVOAxUQ9TOhxE-kEMLQ8LTfT8hf37-uL-4Km7uLq8vvt8UuuJyKoSB1rQcOgQh0NrWNp3NTTIBxgpAUZcGunKj2UaXNYAGU1eC6Q12lWmtOCFfdnu3MTzNmCY1urREAY85lZKyKYXkMoOf_gP7MEefsynORFlz2fIqU9WO0jGkFNGqbXRjPjZDatGverXTrxb9aikm8tjH_fK5G9G8Du19Z-DzHoCkYbBZt3bplZOcl3XVZO7bjsPs7J_DqJJ26DUaF1FPygT3dpIXpgWl0Q</recordid><startdate>20040901</startdate><enddate>20040901</enddate><creator>Ünal, Murat</creator><creator>Tamer, Lülüfer</creator><creator>Aras Ateş, Nurcan</creator><creator>Akbaş, Yücel</creator><creator>Pata, Yavuz Selim</creator><creator>Vayisoğlu, Yusuf</creator><creator>Ercan, Bahadır</creator><creator>Görür, Kemal</creator><creator>Atik, Uğur</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20040901</creationdate><title>Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma</title><author>Ünal, Murat ; Tamer, Lülüfer ; Aras Ateş, Nurcan ; Akbaş, Yücel ; Pata, Yavuz Selim ; Vayisoğlu, Yusuf ; Ercan, Bahadır ; Görür, Kemal ; Atik, Uğur</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-3da9d91abea33eff9f8bfff9603adf3ae352dab27c07c25aacad5430c7eb4d9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - enzymology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Case-Control Studies</topic><topic>DNA, Neoplasm - chemistry</topic><topic>DNA, Neoplasm - isolation & purification</topic><topic>Female</topic><topic>Genotype</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - enzymology</topic><topic>Laryngeal Neoplasms - genetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ünal, Murat</creatorcontrib><creatorcontrib>Tamer, Lülüfer</creatorcontrib><creatorcontrib>Aras Ateş, Nurcan</creatorcontrib><creatorcontrib>Akbaş, Yücel</creatorcontrib><creatorcontrib>Pata, Yavuz Selim</creatorcontrib><creatorcontrib>Vayisoğlu, Yusuf</creatorcontrib><creatorcontrib>Ercan, Bahadır</creatorcontrib><creatorcontrib>Görür, Kemal</creatorcontrib><creatorcontrib>Atik, Uğur</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ünal, Murat</au><au>Tamer, Lülüfer</au><au>Aras Ateş, Nurcan</au><au>Akbaş, Yücel</au><au>Pata, Yavuz Selim</au><au>Vayisoğlu, Yusuf</au><au>Ercan, Bahadır</au><au>Görür, Kemal</au><au>Atik, Uğur</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2004-09-01</date><risdate>2004</risdate><volume>25</volume><issue>5</issue><spage>318</spage><epage>322</epage><pages>318-322</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><coden>AJOTDP</coden><abstract>To investigate the influence of the glutathione S-transferase (GST) M1, T1, and P1 genotypes on the laryngeal squamous cell carcinoma risk.
The study group consisted of 42 white patients with laryngeal squamous cell carcinoma (39 of them were male, mean age: 53, range: 37–67 and 3 of them were female, mean age: 47, range: 32–55) and 89 control subjects (nonsmokers = 47, smokers = 42) (58 male and 31 female, mean age: 51, range: 30–72). DNA samples were isolated from blood samples using high pure polymerase chain reaction (PCR) Template Preparation Kit. The detection of GST T1, GST M1, and P1 polymorphisms were detected by using real-time PCR.
Gene polymorphisms at GST M1 and P1 were not significantly different in patient and control groups. However, GST T1 null type significantly increased in laryngeal cancer patients when compared with the nonsmoking controls (
P = .04).
There was a significant association between GST T1 null genotype and laryngeal squamous cell carcinoma. However the potential role of GSTs as markers of susceptibility to laryngeal carcinoma needs further studies in a larger number of patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>15334395</pmid><doi>10.1016/j.amjoto.2004.04.003</doi><tpages>5</tpages></addata></record> |
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| ispartof | American journal of otolaryngology, 2004-09, Vol.25 (5), p.318-322 |
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| subjects | Adult Aged Biological and medical sciences Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Case-Control Studies DNA, Neoplasm - chemistry DNA, Neoplasm - isolation & purification Female Genotype Glutathione Transferase - genetics Humans Laryngeal Neoplasms - enzymology Laryngeal Neoplasms - genetics Male Medical sciences Middle Aged Otorhinolaryngology. Stomatology Polymerase Chain Reaction Polymorphism, Genetic - genetics Risk Factors Smoking - adverse effects Smoking - genetics Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Glutathione S-transferase M1, T1, and P1 gene polymorphism in laryngeal squamous cell carcinoma |
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