Special issues related to hematopoietic SCT in the Eastern Mediterranean region and the first regional activity report
Although several centers are now performing allogeneic hematopoietic SCT (HSCT) in the Eastern Mediterranean (EM) region, the availability is still limited. Special issues including compatible donor availability and potential for alternative donor programs are discussed. In comparison to Europe and...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2009-01, Vol.43 (1), p.1-12 |
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| creator | Aljurf, M D Zaidi, S Z El Solh, H Hussain, F Ghavamzadeh, A Mahmoud, H K Shamsi, T Othman, T Ben Sarhan, M M Dennison, D Ibrahim, A Benchekroun, S Chaudhri, N Labar, B Horowitz, M Niederwieser, D Gratwohl, A |
| description | Although several centers are now performing allogeneic hematopoietic SCT (HSCT) in the Eastern Mediterranean (EM) region, the availability is still limited. Special issues including compatible donor availability and potential for alternative donor programs are discussed. In comparison to Europe and North America, differences in patterns of diseases and pre-HSCT general status, particularly for patients with BM failure, are described. Other differences including high sero-positivity for CMV, hepatitis B and C infection, and specific observations about GVHD and its relation to genetically homogeneous communities are also discussed. We report that a total of 17 HSCT programs (performing five or more HSCTs annually) exist in 9 countries of the EM region. Only six programs are currently reporting to European Group for Blood and Marrow Transplantation or Center for International Blood and Marrow Transplantation Research. A total of 7617 HSCTs have been performed by these programs including 5701 allogeneic HSCTs. The area has low-HSCT team density (1.56 teams per 10 million inhabitants vs 14.43 in Europe) and very low-HSCT team distribution (0.27 teams per 10 000 sq km area vs |
| doi_str_mv | 10.1038/bmt.2008.389 |
| format | Article |
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Special issues including compatible donor availability and potential for alternative donor programs are discussed. In comparison to Europe and North America, differences in patterns of diseases and pre-HSCT general status, particularly for patients with BM failure, are described. Other differences including high sero-positivity for CMV, hepatitis B and C infection, and specific observations about GVHD and its relation to genetically homogeneous communities are also discussed. We report that a total of 17 HSCT programs (performing five or more HSCTs annually) exist in 9 countries of the EM region. Only six programs are currently reporting to European Group for Blood and Marrow Transplantation or Center for International Blood and Marrow Transplantation Research. A total of 7617 HSCTs have been performed by these programs including 5701 allogeneic HSCTs. The area has low-HSCT team density (1.56 teams per 10 million inhabitants vs 14.43 in Europe) and very low-HSCT team distribution (0.27 teams per 10 000 sq km area vs <1–6 teams in Europe). Gross national income per capita had no clear association with low-HSCT activity. Much improvement in infrastructure and formation of an EM regional HSCT registry are needed.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/bmt.2008.389</identifier><identifier>PMID: 19043456</identifier><identifier>CODEN: BMTRE9</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Analysis ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Bone marrow ; Bone Marrow Transplantation ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Cell Biology ; Data Collection ; Health Services Accessibility ; Hematology ; Hematopoietic Stem Cell Transplantation - utilization ; Hematopoietic stem cells ; Humans ; Internal Medicine ; Management ; Medical care, Cost of ; Medical centers ; Medical sciences ; Medicine ; Medicine & Public Health ; Mediterranean Region ; Polymorphism, Genetic ; Public Health ; Registries ; special-report ; Stem cell transplantation ; Stem Cells ; Tissue Donors - supply & distribution ; Transfusions. Complications. Transfusion reactions. 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Special issues including compatible donor availability and potential for alternative donor programs are discussed. In comparison to Europe and North America, differences in patterns of diseases and pre-HSCT general status, particularly for patients with BM failure, are described. Other differences including high sero-positivity for CMV, hepatitis B and C infection, and specific observations about GVHD and its relation to genetically homogeneous communities are also discussed. We report that a total of 17 HSCT programs (performing five or more HSCTs annually) exist in 9 countries of the EM region. Only six programs are currently reporting to European Group for Blood and Marrow Transplantation or Center for International Blood and Marrow Transplantation Research. A total of 7617 HSCTs have been performed by these programs including 5701 allogeneic HSCTs. The area has low-HSCT team density (1.56 teams per 10 million inhabitants vs 14.43 in Europe) and very low-HSCT team distribution (0.27 teams per 10 000 sq km area vs <1–6 teams in Europe). Gross national income per capita had no clear association with low-HSCT activity. Much improvement in infrastructure and formation of an EM regional HSCT registry are needed.</description><subject>Analysis</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Cell Biology</subject><subject>Data Collection</subject><subject>Health Services Accessibility</subject><subject>Hematology</subject><subject>Hematopoietic Stem Cell Transplantation - utilization</subject><subject>Hematopoietic stem cells</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Management</subject><subject>Medical care, Cost of</subject><subject>Medical centers</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mediterranean Region</subject><subject>Polymorphism, Genetic</subject><subject>Public Health</subject><subject>Registries</subject><subject>special-report</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Tissue Donors - supply & distribution</subject><subject>Transfusions. Complications. Transfusion reactions. 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Special issues including compatible donor availability and potential for alternative donor programs are discussed. In comparison to Europe and North America, differences in patterns of diseases and pre-HSCT general status, particularly for patients with BM failure, are described. Other differences including high sero-positivity for CMV, hepatitis B and C infection, and specific observations about GVHD and its relation to genetically homogeneous communities are also discussed. We report that a total of 17 HSCT programs (performing five or more HSCTs annually) exist in 9 countries of the EM region. Only six programs are currently reporting to European Group for Blood and Marrow Transplantation or Center for International Blood and Marrow Transplantation Research. A total of 7617 HSCTs have been performed by these programs including 5701 allogeneic HSCTs. The area has low-HSCT team density (1.56 teams per 10 million inhabitants vs 14.43 in Europe) and very low-HSCT team distribution (0.27 teams per 10 000 sq km area vs <1–6 teams in Europe). Gross national income per capita had no clear association with low-HSCT activity. Much improvement in infrastructure and formation of an EM regional HSCT registry are needed.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19043456</pmid><doi>10.1038/bmt.2008.389</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0268-3369 1476-5365 |
| language | eng |
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| source | MEDLINE; Nature Journals Online; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | Analysis Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone Marrow Transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Data Collection Health Services Accessibility Hematology Hematopoietic Stem Cell Transplantation - utilization Hematopoietic stem cells Humans Internal Medicine Management Medical care, Cost of Medical centers Medical sciences Medicine Medicine & Public Health Mediterranean Region Polymorphism, Genetic Public Health Registries special-report Stem cell transplantation Stem Cells Tissue Donors - supply & distribution Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - utilization |
| title | Special issues related to hematopoietic SCT in the Eastern Mediterranean region and the first regional activity report |
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