WASP and WAVE proteins: Vital intrinsic regulators of cell motility and their role in cancer (Review)
Cell migration is critical during the metastatic spread of cancer cells. Metastases, rather than primary tumours, are responsible for most cancer-related deaths. Invasive cancer cells acquire a migratory phenotype which is associated with an increased expression of several genes involved in cell mot...
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| Veröffentlicht in: | International journal of molecular medicine 2009-02, Vol.23 (2), p.141-148 |
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| container_title | International journal of molecular medicine |
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| creator | Fernando, Herman Kynaston, Howard Jiang, Wen |
| description | Cell migration is critical during the metastatic spread of cancer cells.
Metastases, rather than primary tumours, are responsible for most cancer-related
deaths. Invasive cancer cells acquire a migratory phenotype which is associated
with an increased expression of several genes involved in cell motility. Actin,
which is the most abundant protein in most eukaryotic cells, is necessary for
whole cell locomotion. Reorganisation of actin filaments is regulated by a highly
integrated signalling cascade governed by ‘molecular switches’ which belong to
the Rho GTPase family. WASP family proteins are downstream molecules which form
a link between the GTPases and the actin cytoskeleton. The WASP family includes
5 members and is structurally divided into 2 groups: Wiskott-Aldrich Syndrome
proteins (WASPs) and WASP verprolin homologous proteins (WAVEs). Current evidence
suggests that WAVEs are crucial for cell motility and metastasis. This is a review
on the possible role of WAVEs in cancer and the clinical associations found in
human cancer. |
| doi_str_mv | 10.3892/ijmm_00000111 |
| format | Article |
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Metastases, rather than primary tumours, are responsible for most cancer-related
deaths. Invasive cancer cells acquire a migratory phenotype which is associated
with an increased expression of several genes involved in cell motility. Actin,
which is the most abundant protein in most eukaryotic cells, is necessary for
whole cell locomotion. Reorganisation of actin filaments is regulated by a highly
integrated signalling cascade governed by ‘molecular switches’ which belong to
the Rho GTPase family. WASP family proteins are downstream molecules which form
a link between the GTPases and the actin cytoskeleton. The WASP family includes
5 members and is structurally divided into 2 groups: Wiskott-Aldrich Syndrome
proteins (WASPs) and WASP verprolin homologous proteins (WAVEs). Current evidence
suggests that WAVEs are crucial for cell motility and metastasis. This is a review
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Metastases, rather than primary tumours, are responsible for most cancer-related
deaths. Invasive cancer cells acquire a migratory phenotype which is associated
with an increased expression of several genes involved in cell motility. Actin,
which is the most abundant protein in most eukaryotic cells, is necessary for
whole cell locomotion. Reorganisation of actin filaments is regulated by a highly
integrated signalling cascade governed by ‘molecular switches’ which belong to
the Rho GTPase family. WASP family proteins are downstream molecules which form
a link between the GTPases and the actin cytoskeleton. The WASP family includes
5 members and is structurally divided into 2 groups: Wiskott-Aldrich Syndrome
proteins (WASPs) and WASP verprolin homologous proteins (WAVEs). Current evidence
suggests that WAVEs are crucial for cell motility and metastasis. This is a review
on the possible role of WAVEs in cancer and the clinical associations found in
human cancer.</description><subject>Actin-Related Protein 2-3 Complex - metabolism</subject><subject>Cell Movement - physiology</subject><subject>Conserved Sequence</subject><subject>Humans</subject><subject>Neoplasms - metabolism</subject><subject>Wiskott-Aldrich Syndrome Protein - metabolism</subject><subject>Wiskott-Aldrich Syndrome Protein Family - metabolism</subject><issn>1107-3756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkctLAzEQxnNQbK0evUpOoshqXvvyVkp9QEHx0R6XbDKrKfuoSar0vze1leJchoHfN8z3DUInlFzxLGfXZt40BVkXpXQP9SklacTTOOmhQ-fmhLBY5NkB6tGciizmaR_BbPjyhGWr8Ww4HeOF7TyY1t3gqfGyxqb1NoxGYQvvy1r6zjrcVVhBXeOm86Y2fvUr9x9gLLZdDUGElWwVWHz-DF8Gvi-O0H4lawfH2z5Ab7fj19F9NHm8exgNJ5HijPmoYrpkTJQ01RXPMiZYSYSQLKVZcKJVAqBizbhISkpVyYMI4pznQgMlUig-QGebvcHH5xKcLxrj1rfKFrqlK5IkYyxncQCjDahs55yFqlhY00i7Kigp1lkW_7IM_Ol28bJsQO_obZABuNwAbhHSMLpzO-bvC4wzKmgQ8B9tEn5o</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Fernando, Herman</creator><creator>Kynaston, Howard</creator><creator>Jiang, Wen</creator><general>D.A. Spandidos</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20090201</creationdate><title>WASP and WAVE proteins: Vital intrinsic regulators of cell motility and their role in cancer (Review)</title><author>Fernando, Herman ; Kynaston, Howard ; Jiang, Wen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c322t-f2db224b17df388242b044a2718107dc6eec5d2346b11cb3322e59394de10a4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Actin-Related Protein 2-3 Complex - metabolism</topic><topic>Cell Movement - physiology</topic><topic>Conserved Sequence</topic><topic>Humans</topic><topic>Neoplasms - metabolism</topic><topic>Wiskott-Aldrich Syndrome Protein - metabolism</topic><topic>Wiskott-Aldrich Syndrome Protein Family - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernando, Herman</creatorcontrib><creatorcontrib>Kynaston, Howard</creatorcontrib><creatorcontrib>Jiang, Wen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of molecular medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernando, Herman</au><au>Kynaston, Howard</au><au>Jiang, Wen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>WASP and WAVE proteins: Vital intrinsic regulators of cell motility and their role in cancer (Review)</atitle><jtitle>International journal of molecular medicine</jtitle><addtitle>Int J Mol Med</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>23</volume><issue>2</issue><spage>141</spage><epage>148</epage><pages>141-148</pages><issn>1107-3756</issn><abstract>Cell migration is critical during the metastatic spread of cancer cells.
Metastases, rather than primary tumours, are responsible for most cancer-related
deaths. Invasive cancer cells acquire a migratory phenotype which is associated
with an increased expression of several genes involved in cell motility. Actin,
which is the most abundant protein in most eukaryotic cells, is necessary for
whole cell locomotion. Reorganisation of actin filaments is regulated by a highly
integrated signalling cascade governed by ‘molecular switches’ which belong to
the Rho GTPase family. WASP family proteins are downstream molecules which form
a link between the GTPases and the actin cytoskeleton. The WASP family includes
5 members and is structurally divided into 2 groups: Wiskott-Aldrich Syndrome
proteins (WASPs) and WASP verprolin homologous proteins (WAVEs). Current evidence
suggests that WAVEs are crucial for cell motility and metastasis. This is a review
on the possible role of WAVEs in cancer and the clinical associations found in
human cancer.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>19148537</pmid><doi>10.3892/ijmm_00000111</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1107-3756 |
| ispartof | International journal of molecular medicine, 2009-02, Vol.23 (2), p.141-148 |
| issn | 1107-3756 |
| language | eng |
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| source | Spandidos Publications Journals; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Actin-Related Protein 2-3 Complex - metabolism Cell Movement - physiology Conserved Sequence Humans Neoplasms - metabolism Wiskott-Aldrich Syndrome Protein - metabolism Wiskott-Aldrich Syndrome Protein Family - metabolism |
| title | WASP and WAVE proteins: Vital intrinsic regulators of cell motility and their role in cancer (Review) |
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