Insulin-like growth factor II induces apoptosis in osteoblasts

The ability of insulin-like growth factor II (IGF-II) to modulate apoptosis was studied in murine osteoblasts. At 72 h of culture, 0.01, 0.1, and 1.0 nM IGF-II produced a dose-dependent increase in apoptosis assayed by TdT-mediated dUTP-biotin nick end labeling (TUNEL) and confirmed with acridine or...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2004-09, Vol.35 (3), p.621-628
Hauptverfasser:	Gronowicz, Gloria A., McCarthy, Mary-Beth, Zhang, Hai, Zhang, Wenjian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Bax Bcl-2 Biological and medical sciences Bone Cell Count - methods Cells, Cultured Diseases of the osteoarticular system Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Humans Insulin growth factor-II (IGF-II) Insulin-Like Growth Factor II - pharmacology Medical sciences Mice Mice, Transgenic Osteoblasts Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - physiology Traumas. Diseases due to physical agents Vertebrates: anatomy and physiology, studies on body, several organs or systems
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