Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor
Summary The common beta chain subunit (βc), also known as CDw131, shared by the interleukin‐3 (IL‐3), granulocytic macrophage colony‐stimulating factor (GM‐CSF) and IL‐5 receptors, is required for high‐affinity ligand binding and signal transduction. The present study explored the expression of CDw1...
Gespeichert in:
| Veröffentlicht in: | British journal of haematology 2009-02, Vol.144 (3), p.376-387 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 387 |
|---|---|
| container_issue | 3 |
| container_start_page | 376 |
| container_title | British journal of haematology |
| container_volume | 144 |
| creator | Riccioni, Roberta Diverio, Daniela Riti, Viviana Buffolino, Sonia Mariani, Gualtiero Boe, Alessandra Cedrone, Michele Ottone, Tiziana Foà, Robin Testa, Ugo |
| description | Summary
The common beta chain subunit (βc), also known as CDw131, shared by the interleukin‐3 (IL‐3), granulocytic macrophage colony‐stimulating factor (GM‐CSF) and IL‐5 receptors, is required for high‐affinity ligand binding and signal transduction. The present study explored the expression of CDw131 in 105 de novo cases of acute myeloid leukaemia (AML). The levels of CDw131 expression were used to identify two AML subgroups characterized by low (75/105) and high (30/105) expression of this receptor chain. It was observed that (i) the level of CDw131 expression strictly correlated with the level of CD116 (GM‐CSFα receptor chain) and CD123 (IL‐3Rα chain); (ii) AMLs with high CDw131 expression were characterized by low CD34 expression and usually high CD11b, CD14 expression; (iii) AMLs with high CDw131 expression frequently co‐expressed receptors for angiogenic growth factors (vascular endothelial growth factor R2, Tie‐2); (iv) AMLs with high CDw131 expression were more cycling than those with low CDw131 expression; (v) AMLs with high CDw131 frequently displayed Feline Murine Sarcoma (FMS‐related) tyrosine kinase 3 (FLT3) internal tandem duplication and constitutively activated Signal Transducer and Activator of Transcription‐5 (STAT5). In conclusion, the analysis of the level of CDw131 expression enabled the identification of a subset of AMLs characterized by a high cycling status, the expression of myelo‐monocytic markers, mutated FLT3 and the co‐expression of receptors for angiogenic growth factors. These findings are of value for the development of new therapeutic strategies for the treatment of these AMLs. |
| doi_str_mv | 10.1111/j.1365-2141.2008.07491.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_66820992</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20347373</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4481-30076ba29c706be246ca92de23d85a0c001be4d90159c783d6127276bd6b1ab23</originalsourceid><addsrcrecordid>eNqNUs2O0zAQjhCILQuvgHxCcEjqnzQ_Bw6wYtmiIg7A2Zo409bFcYLtaJsbj8ADcuJJcLbVcgRf7Jn5vpnxN5MkhNGMxbM8ZEwUq5SznGWc0iqjZV6z7PggWdwHHiYLSmmZMppXF8kT7w-UMkFX7HFywWoqClqJRfJrbQM6g-M3bcnL9ebV7x8_xXLnwI6mV1NA0oFy_bCHHcaQ6k1vJ-KD7kYDQdsd2YIKvVuuNzG8Ig4VDtEmYCKHgG1JgwGI2oO2noBDMjjcokMbNBgzETxGh_fYktgBqHEuOaHpdUvmtgA7DZ7c6rAn3RggROD1x8-xmENzZ4XJ9V5bJPEL4JGI-yaeJo-2YDw-O9-Xydfrd1-ubtLNp_frqzebVOV5xVIRZSoa4LUqadEgzwsFNW-Ri7ZaAVVRtwbztqZsFSGVaAvGSx4pbdEwaLi4TF6c8g6u_z6iD7LTXqExYLEfvSyKitO6_jeQU5GXohQRWJ2AUXvvo2BycLoDN0lG5bwC8iDnSct50nJeAXm3AvIYqc_PNcamw_Yv8TzzCHh9Atxqg9N_J5ZvP9zML_EHAMHICw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20347373</pqid></control><display><type>article</type><title>Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Riccioni, Roberta ; Diverio, Daniela ; Riti, Viviana ; Buffolino, Sonia ; Mariani, Gualtiero ; Boe, Alessandra ; Cedrone, Michele ; Ottone, Tiziana ; Foà, Robin ; Testa, Ugo</creator><creatorcontrib>Riccioni, Roberta ; Diverio, Daniela ; Riti, Viviana ; Buffolino, Sonia ; Mariani, Gualtiero ; Boe, Alessandra ; Cedrone, Michele ; Ottone, Tiziana ; Foà, Robin ; Testa, Ugo</creatorcontrib><description>Summary
The common beta chain subunit (βc), also known as CDw131, shared by the interleukin‐3 (IL‐3), granulocytic macrophage colony‐stimulating factor (GM‐CSF) and IL‐5 receptors, is required for high‐affinity ligand binding and signal transduction. The present study explored the expression of CDw131 in 105 de novo cases of acute myeloid leukaemia (AML). The levels of CDw131 expression were used to identify two AML subgroups characterized by low (75/105) and high (30/105) expression of this receptor chain. It was observed that (i) the level of CDw131 expression strictly correlated with the level of CD116 (GM‐CSFα receptor chain) and CD123 (IL‐3Rα chain); (ii) AMLs with high CDw131 expression were characterized by low CD34 expression and usually high CD11b, CD14 expression; (iii) AMLs with high CDw131 expression frequently co‐expressed receptors for angiogenic growth factors (vascular endothelial growth factor R2, Tie‐2); (iv) AMLs with high CDw131 expression were more cycling than those with low CDw131 expression; (v) AMLs with high CDw131 frequently displayed Feline Murine Sarcoma (FMS‐related) tyrosine kinase 3 (FLT3) internal tandem duplication and constitutively activated Signal Transducer and Activator of Transcription‐5 (STAT5). In conclusion, the analysis of the level of CDw131 expression enabled the identification of a subset of AMLs characterized by a high cycling status, the expression of myelo‐monocytic markers, mutated FLT3 and the co‐expression of receptors for angiogenic growth factors. These findings are of value for the development of new therapeutic strategies for the treatment of these AMLs.</description><identifier>ISSN: 0007-1048</identifier><identifier>EISSN: 1365-2141</identifier><identifier>DOI: 10.1111/j.1365-2141.2008.07491.x</identifier><identifier>PMID: 19036083</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Biomarkers - analysis ; Blotting, Western - methods ; Cytokine Receptor Common beta Subunit - analysis ; Cytokine Receptor Common beta Subunit - metabolism ; Flow Cytometry ; fms-Like Tyrosine Kinase 3 - genetics ; Gene Expression Regulation, Leukemic ; granulo‐monocytic colony stimulating factor ; growth factor receptors ; Humans ; Immunophenotyping ; Interleukin-3 Receptor alpha Subunit - analysis ; Interleukin-5 Receptor alpha Subunit - metabolism ; interleukin‐3 ; leukaemia ; Leukemia, Myeloid, Acute - immunology ; Leukocyte Count ; Mutation ; mutations ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - analysis ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Translocation, Genetic ; Tumor Cells, Cultured ; Vascular Endothelial Growth Factor Receptor-2 - analysis</subject><ispartof>British journal of haematology, 2009-02, Vol.144 (3), p.376-387</ispartof><rights>2008 The Authors. Journal Compilation © 2008 Blackwell Publishing Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4481-30076ba29c706be246ca92de23d85a0c001be4d90159c783d6127276bd6b1ab23</citedby><cites>FETCH-LOGICAL-c4481-30076ba29c706be246ca92de23d85a0c001be4d90159c783d6127276bd6b1ab23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2141.2008.07491.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2141.2008.07491.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27902,27903,45552,45553,46386,46810</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19036083$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riccioni, Roberta</creatorcontrib><creatorcontrib>Diverio, Daniela</creatorcontrib><creatorcontrib>Riti, Viviana</creatorcontrib><creatorcontrib>Buffolino, Sonia</creatorcontrib><creatorcontrib>Mariani, Gualtiero</creatorcontrib><creatorcontrib>Boe, Alessandra</creatorcontrib><creatorcontrib>Cedrone, Michele</creatorcontrib><creatorcontrib>Ottone, Tiziana</creatorcontrib><creatorcontrib>Foà, Robin</creatorcontrib><creatorcontrib>Testa, Ugo</creatorcontrib><title>Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor</title><title>British journal of haematology</title><addtitle>Br J Haematol</addtitle><description>Summary
The common beta chain subunit (βc), also known as CDw131, shared by the interleukin‐3 (IL‐3), granulocytic macrophage colony‐stimulating factor (GM‐CSF) and IL‐5 receptors, is required for high‐affinity ligand binding and signal transduction. The present study explored the expression of CDw131 in 105 de novo cases of acute myeloid leukaemia (AML). The levels of CDw131 expression were used to identify two AML subgroups characterized by low (75/105) and high (30/105) expression of this receptor chain. It was observed that (i) the level of CDw131 expression strictly correlated with the level of CD116 (GM‐CSFα receptor chain) and CD123 (IL‐3Rα chain); (ii) AMLs with high CDw131 expression were characterized by low CD34 expression and usually high CD11b, CD14 expression; (iii) AMLs with high CDw131 expression frequently co‐expressed receptors for angiogenic growth factors (vascular endothelial growth factor R2, Tie‐2); (iv) AMLs with high CDw131 expression were more cycling than those with low CDw131 expression; (v) AMLs with high CDw131 frequently displayed Feline Murine Sarcoma (FMS‐related) tyrosine kinase 3 (FLT3) internal tandem duplication and constitutively activated Signal Transducer and Activator of Transcription‐5 (STAT5). In conclusion, the analysis of the level of CDw131 expression enabled the identification of a subset of AMLs characterized by a high cycling status, the expression of myelo‐monocytic markers, mutated FLT3 and the co‐expression of receptors for angiogenic growth factors. These findings are of value for the development of new therapeutic strategies for the treatment of these AMLs.</description><subject>Biomarkers - analysis</subject><subject>Blotting, Western - methods</subject><subject>Cytokine Receptor Common beta Subunit - analysis</subject><subject>Cytokine Receptor Common beta Subunit - metabolism</subject><subject>Flow Cytometry</subject><subject>fms-Like Tyrosine Kinase 3 - genetics</subject><subject>Gene Expression Regulation, Leukemic</subject><subject>granulo‐monocytic colony stimulating factor</subject><subject>growth factor receptors</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Interleukin-3 Receptor alpha Subunit - analysis</subject><subject>Interleukin-5 Receptor alpha Subunit - metabolism</subject><subject>interleukin‐3</subject><subject>leukaemia</subject><subject>Leukemia, Myeloid, Acute - immunology</subject><subject>Leukocyte Count</subject><subject>Mutation</subject><subject>mutations</subject><subject>Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - analysis</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - methods</subject><subject>Translocation, Genetic</subject><subject>Tumor Cells, Cultured</subject><subject>Vascular Endothelial Growth Factor Receptor-2 - analysis</subject><issn>0007-1048</issn><issn>1365-2141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUs2O0zAQjhCILQuvgHxCcEjqnzQ_Bw6wYtmiIg7A2Zo409bFcYLtaJsbj8ADcuJJcLbVcgRf7Jn5vpnxN5MkhNGMxbM8ZEwUq5SznGWc0iqjZV6z7PggWdwHHiYLSmmZMppXF8kT7w-UMkFX7HFywWoqClqJRfJrbQM6g-M3bcnL9ebV7x8_xXLnwI6mV1NA0oFy_bCHHcaQ6k1vJ-KD7kYDQdsd2YIKvVuuNzG8Ig4VDtEmYCKHgG1JgwGI2oO2noBDMjjcokMbNBgzETxGh_fYktgBqHEuOaHpdUvmtgA7DZ7c6rAn3RggROD1x8-xmENzZ4XJ9V5bJPEL4JGI-yaeJo-2YDw-O9-Xydfrd1-ubtLNp_frqzebVOV5xVIRZSoa4LUqadEgzwsFNW-Ri7ZaAVVRtwbztqZsFSGVaAvGSx4pbdEwaLi4TF6c8g6u_z6iD7LTXqExYLEfvSyKitO6_jeQU5GXohQRWJ2AUXvvo2BycLoDN0lG5bwC8iDnSct50nJeAXm3AvIYqc_PNcamw_Yv8TzzCHh9Atxqg9N_J5ZvP9zML_EHAMHICw</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Riccioni, Roberta</creator><creator>Diverio, Daniela</creator><creator>Riti, Viviana</creator><creator>Buffolino, Sonia</creator><creator>Mariani, Gualtiero</creator><creator>Boe, Alessandra</creator><creator>Cedrone, Michele</creator><creator>Ottone, Tiziana</creator><creator>Foà, Robin</creator><creator>Testa, Ugo</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200902</creationdate><title>Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor</title><author>Riccioni, Roberta ; Diverio, Daniela ; Riti, Viviana ; Buffolino, Sonia ; Mariani, Gualtiero ; Boe, Alessandra ; Cedrone, Michele ; Ottone, Tiziana ; Foà, Robin ; Testa, Ugo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4481-30076ba29c706be246ca92de23d85a0c001be4d90159c783d6127276bd6b1ab23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biomarkers - analysis</topic><topic>Blotting, Western - methods</topic><topic>Cytokine Receptor Common beta Subunit - analysis</topic><topic>Cytokine Receptor Common beta Subunit - metabolism</topic><topic>Flow Cytometry</topic><topic>fms-Like Tyrosine Kinase 3 - genetics</topic><topic>Gene Expression Regulation, Leukemic</topic><topic>granulo‐monocytic colony stimulating factor</topic><topic>growth factor receptors</topic><topic>Humans</topic><topic>Immunophenotyping</topic><topic>Interleukin-3 Receptor alpha Subunit - analysis</topic><topic>Interleukin-5 Receptor alpha Subunit - metabolism</topic><topic>interleukin‐3</topic><topic>leukaemia</topic><topic>Leukemia, Myeloid, Acute - immunology</topic><topic>Leukocyte Count</topic><topic>Mutation</topic><topic>mutations</topic><topic>Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - analysis</topic><topic>Reverse Transcriptase Polymerase Chain Reaction - methods</topic><topic>Translocation, Genetic</topic><topic>Tumor Cells, Cultured</topic><topic>Vascular Endothelial Growth Factor Receptor-2 - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riccioni, Roberta</creatorcontrib><creatorcontrib>Diverio, Daniela</creatorcontrib><creatorcontrib>Riti, Viviana</creatorcontrib><creatorcontrib>Buffolino, Sonia</creatorcontrib><creatorcontrib>Mariani, Gualtiero</creatorcontrib><creatorcontrib>Boe, Alessandra</creatorcontrib><creatorcontrib>Cedrone, Michele</creatorcontrib><creatorcontrib>Ottone, Tiziana</creatorcontrib><creatorcontrib>Foà, Robin</creatorcontrib><creatorcontrib>Testa, Ugo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of haematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riccioni, Roberta</au><au>Diverio, Daniela</au><au>Riti, Viviana</au><au>Buffolino, Sonia</au><au>Mariani, Gualtiero</au><au>Boe, Alessandra</au><au>Cedrone, Michele</au><au>Ottone, Tiziana</au><au>Foà, Robin</au><au>Testa, Ugo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor</atitle><jtitle>British journal of haematology</jtitle><addtitle>Br J Haematol</addtitle><date>2009-02</date><risdate>2009</risdate><volume>144</volume><issue>3</issue><spage>376</spage><epage>387</epage><pages>376-387</pages><issn>0007-1048</issn><eissn>1365-2141</eissn><abstract>Summary
The common beta chain subunit (βc), also known as CDw131, shared by the interleukin‐3 (IL‐3), granulocytic macrophage colony‐stimulating factor (GM‐CSF) and IL‐5 receptors, is required for high‐affinity ligand binding and signal transduction. The present study explored the expression of CDw131 in 105 de novo cases of acute myeloid leukaemia (AML). The levels of CDw131 expression were used to identify two AML subgroups characterized by low (75/105) and high (30/105) expression of this receptor chain. It was observed that (i) the level of CDw131 expression strictly correlated with the level of CD116 (GM‐CSFα receptor chain) and CD123 (IL‐3Rα chain); (ii) AMLs with high CDw131 expression were characterized by low CD34 expression and usually high CD11b, CD14 expression; (iii) AMLs with high CDw131 expression frequently co‐expressed receptors for angiogenic growth factors (vascular endothelial growth factor R2, Tie‐2); (iv) AMLs with high CDw131 expression were more cycling than those with low CDw131 expression; (v) AMLs with high CDw131 frequently displayed Feline Murine Sarcoma (FMS‐related) tyrosine kinase 3 (FLT3) internal tandem duplication and constitutively activated Signal Transducer and Activator of Transcription‐5 (STAT5). In conclusion, the analysis of the level of CDw131 expression enabled the identification of a subset of AMLs characterized by a high cycling status, the expression of myelo‐monocytic markers, mutated FLT3 and the co‐expression of receptors for angiogenic growth factors. These findings are of value for the development of new therapeutic strategies for the treatment of these AMLs.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19036083</pmid><doi>10.1111/j.1365-2141.2008.07491.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1048 |
| ispartof | British journal of haematology, 2009-02, Vol.144 (3), p.376-387 |
| issn | 0007-1048 1365-2141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_66820992 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biomarkers - analysis Blotting, Western - methods Cytokine Receptor Common beta Subunit - analysis Cytokine Receptor Common beta Subunit - metabolism Flow Cytometry fms-Like Tyrosine Kinase 3 - genetics Gene Expression Regulation, Leukemic granulo‐monocytic colony stimulating factor growth factor receptors Humans Immunophenotyping Interleukin-3 Receptor alpha Subunit - analysis Interleukin-5 Receptor alpha Subunit - metabolism interleukin‐3 leukaemia Leukemia, Myeloid, Acute - immunology Leukocyte Count Mutation mutations Receptors, Granulocyte-Macrophage Colony-Stimulating Factor - analysis Reverse Transcriptase Polymerase Chain Reaction - methods Translocation, Genetic Tumor Cells, Cultured Vascular Endothelial Growth Factor Receptor-2 - analysis |
| title | Interleukin (IL)‐3/granulocyte macrophage‐colony stimulating factor/IL‐5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS‐related tyrosine kinase 3 receptor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T08%3A26%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Interleukin%20(IL)%E2%80%903/granulocyte%20macrophage%E2%80%90colony%20stimulating%20factor/IL%E2%80%905%20receptor%20alpha%20and%20beta%20chains%20are%20preferentially%20expressed%20in%20acute%20myeloid%20leukaemias%20with%20mutated%20FMS%E2%80%90related%20tyrosine%20kinase%203%20receptor&rft.jtitle=British%20journal%20of%20haematology&rft.au=Riccioni,%20Roberta&rft.date=2009-02&rft.volume=144&rft.issue=3&rft.spage=376&rft.epage=387&rft.pages=376-387&rft.issn=0007-1048&rft.eissn=1365-2141&rft_id=info:doi/10.1111/j.1365-2141.2008.07491.x&rft_dat=%3Cproquest_cross%3E20347373%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20347373&rft_id=info:pmid/19036083&rfr_iscdi=true |