Mathematical modelling of the influence of heat shock proteins on cancer invasion of tissue

Tumour cell invasion is crucial for cancer metastasis, which is the main cause of cancer mortality. An important group of proteins involved in cancer invasion are the Heat Shock Proteins (HSPs). According to experimental data, inhibition of one of these proteins, Hsp90, slows down cancer cells while...

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Veröffentlicht in:	Journal of mathematical biology 2009-04, Vol.58 (4-5), p.819-844
Hauptverfasser:	Szymaska, Zuzanna, Urbaski, Jakub, Marciniak-czochra, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applications of Mathematics Biomechanical Phenomena Breast Neoplasms - pathology Breast Neoplasms - physiopathology Cancer invasion Cell Count Cell Line, Tumor Computer Simulation Extracellular Matrix - physiology Female Haptotaxis heat shock proteins Heat-Shock Proteins - physiology HSP90 Heat-Shock Proteins - physiology Humans Mathematical and Computational Biology Mathematical Concepts Mathematics Mathematics and Statistics Matrix Metalloproteinases - physiology Models, Biological Neoplasm Invasiveness - pathology Neoplasm Invasiveness - physiopathology Neoplasm Proteins - physiology
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